Literature DB >> 6306274

Replication of herpes simplex virus type 1 on hydroxyurea-resistant baby hamster kidney cells.

K Leary, J Bratton, B Francke.   

Abstract

Hydroxyurea-resistant (HUr) baby hamster kidney cells were isolated, subcloned, and characterized. One clonal line, which contained elevated levels of ribonucleotide reductase, lost its HU resistance during passage in the absence of the inhibitor, whereas another clonal line was stably resistant. The replication of herpes simplex virus type 1 on these cells was compared with that of the parvovirus minute virus of mice. Herpes simplex virus type 1 was found to be as sensitive to HU on both lines of HUr baby hamster kidney cells as it was on parental (HU-sensitive) cells, whereas parvovirus replication was about eight times more resistant on HUr baby hamster kidney cells compared with the parental cells. The results suggest that herpes simplex virus type 1 cannot use the cellular reductase and may code for its own.

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Year:  1983        PMID： 6306274      PMCID： PMC255234     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  21 in total

1.  Replication of equine herpesvirus type I: resistance to hydroxyurea.

Authors:  J C Cohen; M L Perdue; C C Randall; D J O'Callaghan
Journal:  Virology       Date:  1975-09       Impact factor: 3.616

2.  Cell-free synthesis of herpes simplex virus DNA: conditions for optimal synthesis.

Authors:  B Francke
Journal:  Biochemistry       Date:  1977-12-27       Impact factor: 3.162

3.  A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

Authors:  M M Bradford
Journal:  Anal Biochem       Date:  1976-05-07       Impact factor: 3.365

4.  Transcription of the herpes simplex virus genome in human cells.

Authors:  E K Wagner; R I Swanstrom; M G Stafford
Journal:  J Virol       Date:  1972-10       Impact factor: 5.103

5.  Electron microscopy of herpes simplex virus. 3. Effect of hydroxyurea.

Authors:  S Nii; H S Rosenkranz; C Morgan; H M Rose
Journal:  J Virol       Date:  1968-10       Impact factor: 5.103

6.  Replication of the parvovirus MVM. I. Dependence of virus multiplication and plaque formation on cell growth.

Authors:  P Tattersall
Journal:  J Virol       Date:  1972-10       Impact factor: 5.103

7.  Deoxyribonucleoside triphosphate pools in herpes simplex type 1 infected cells.

Authors:  A T Jamieson; G Bjursell
Journal:  J Gen Virol       Date:  1976-04       Impact factor: 3.891

8.  Ribonucleotide reductase from herpes simplex virus (types 1 and 2) infected and uninfected KB cells: properties of the partially purified enzymes.

Authors:  M Ponce de Leon; R J Eisenberg; G H Cohen
Journal:  J Gen Virol       Date:  1977-07       Impact factor: 3.891

9.  Ribonucleotide reductase activity of synchronized KB cells infected with herpes simplex virus.

Authors:  G H Cohen
Journal:  J Virol       Date:  1972-03       Impact factor: 5.103

10.  Genetic characterization of hydroxyurea-resistance in Chinese hamster ovary cells.

Authors:  W H Lewis; J A Wright
Journal:  J Cell Physiol       Date:  1978-10       Impact factor: 6.384
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  3 in total

1.  Herpes simplex virus type 1-induced ribonucleotide reductase activity is dispensable for virus growth and DNA synthesis: isolation and characterization of an ICP6 lacZ insertion mutant.

Authors:  D J Goldstein; S K Weller
Journal:  J Virol       Date:  1988-01       Impact factor: 5.103

2.  Potentiation of antiherpetic activity of acyclovir by ribonucleotide reductase inhibition.

Authors:  T Spector; D R Averett; D J Nelson; C U Lambe; R W Morrison; M H St Clair; P A Furman
Journal:  Proc Natl Acad Sci U S A       Date:  1985-06       Impact factor: 11.205

3.  2-Acetylpyridine 5-[(dimethylamino)thiocarbonyl]-thiocarbonohydrazone (A1110U), a potent inactivator of ribonucleotide reductases of herpes simplex and varicella-zoster viruses and a potentiator of acyclovir.

Authors:  T Spector; J A Harrington; R W Morrison; C U Lambe; D J Nelson; D R Averett; K Biron; P A Furman
Journal:  Proc Natl Acad Sci U S A       Date:  1989-02       Impact factor: 11.205
  3 in total

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