Literature DB >> 6305909

An indispensable gene for NAD biosynthesis in Salmonella typhimurium.

K T Hughes, D Ladika, J R Roth, B M Olivera.   

Abstract

We have located the nadD locus between lip and leuS at 14 min on the Salmonella typhimurium chromosome, and we have shown it to be the structural gene for nicotinic acid mononucleotide adenylyltransferase. This is the first indispensable gene of pyridine nucleotide metabolism that has been identified. Mutants altered at this locus, isolated by their 6-aminonicotinamide resistance phenotype, accumulate abnormally large pools of nicotinic acid mononucleotide in vivo; many exhibit a temperature-sensitive lethal phenotype. Enzyme assays reveal markedly lower transferase activity in mutant extracts than in nadD+ extracts. The partial dominance of nadD mutants when placed in a nadD+/nadD diploid suggests that nicotinic acid mononucleotide adenylyltransferase is a multimeric enzyme.

Entities:  

Mesh：

Substances：

Year:  1983        PMID： 6305909      PMCID： PMC217671          DOI： 10.1128/jb.155.1.213-221.1983

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  16 in total

1.  Acetylornithinase of Escherichia coli: partial purification and some properties.

Authors:  H J VOGEL; D M BONNER
Journal:  J Biol Chem       Date:  1956-01       Impact factor: 5.157

2.  Hfr formation directed by tn10.

Authors:  F G Chumley; R Menzel; J R Roth
Journal:  Genetics       Date:  1979-04       Impact factor: 4.562

Review 3.  Linkage map of Salmonella typhimurium, edition V.

Authors:  K E Sanderson; P E Hartman
Journal:  Microbiol Rev       Date:  1978-06

4.  Biosynthesis of diphosphopyridine nucleotide. The purification and the properties of diphospyridine nucleotide synthetase from Escherichia coli b.

Authors:  R L Spencer; J Preiss
Journal:  J Biol Chem       Date:  1967-02-10       Impact factor: 5.157

5.  The deamido-diphosphopyridine nucleotide and diphosphopyridine nucleotide pyrophosphorylases of Escherichia coli and yeast.

Authors:  W Dahmen; B Webb; J Preiss
Journal:  Arch Biochem Biophys       Date:  1967-05       Impact factor: 4.013

6.  A method for detection of phage mutants with altered transducing ability.

Authors:  H Schmieger
Journal:  Mol Gen Genet       Date:  1971

Review 7.  Nicotinamide adenine dinucleotide biosynthesis and pyridine nucleotide cycle metabolism in microbial systems.

Authors:  J W Foster; A G Moat
Journal:  Microbiol Rev       Date:  1980-03

Review 8.  Linkage map of Escherichia coli K-12, edition 6.

Authors:  B J Bachmann; K B Low
Journal:  Microbiol Rev       Date:  1980-03

9.  Abstracts of papers presented at the 1980 meetings of the Genetic Society of America. Boulder, Colorado August 18-20, 1980.

Authors: 
Journal:  Genetics       Date:  1980       Impact factor: 4.562

10.  Regulation of branched-chain amino acid biosynthesis in Salmonella typhimurium: isolation of regulatory mutants.

Authors:  J M Calvo; M Freundlich; H E Umbarger
Journal:  J Bacteriol       Date:  1969-03       Impact factor: 3.490
View more
  20 in total

1.  Identification of the Escherichia coli nicotinic acid mononucleotide adenylyltransferase gene.

Authors:  R A Mehl; C Kinsland; T P Begley
Journal:  J Bacteriol       Date:  2000-08       Impact factor: 3.490

2.  Identification of the archaeal NMN adenylytransferase gene.

Authors:  N Raffaelli; M Emanuelli; F M Pisani; A Amici; T Lorenzi; S Ruggieri; G Magni
Journal:  Mol Cell Biochem       Date:  1999-03       Impact factor: 3.396

3.  Adaptive mutation: general mutagenesis is not a programmed response to stress but results from rare coamplification of dinB with lac.

Authors:  E Susan Slechta; Kim L Bunny; Elisabeth Kugelberg; Eric Kofoid; Dan I Andersson; John R Roth
Journal:  Proc Natl Acad Sci U S A       Date:  2003-10-14       Impact factor: 11.205

4.  Characterization of nicotinamide mononucleotide adenylyltransferase from thermophilic archaea.

Authors:  N Raffaelli; F M Pisani; T Lorenzi; M Emanuelli; A Amici; S Ruggieri; G Magni
Journal:  J Bacteriol       Date:  1997-12       Impact factor: 3.490

Review 5.  Linkage map of Salmonella typhimurium, edition VII.

Authors:  K E Sanderson; J R Roth
Journal:  Microbiol Rev       Date:  1988-12

6.  Genetic characterization and regulation of the nadB locus of Salmonella typhimurium.

Authors:  B T Cookson; B M Olivera; J R Roth
Journal:  J Bacteriol       Date:  1987-09       Impact factor: 3.490

7.  Regulation of NAD metabolism in Salmonella typhimurium: genetic analysis and cloning of the nadR repressor locus.

Authors:  J W Foster; E A Holley-Guthrie; F Warren
Journal:  Mol Gen Genet       Date:  1987-06

8.  From genetic footprinting to antimicrobial drug targets: examples in cofactor biosynthetic pathways.

Authors:  Svetlana Y Gerdes; Michael D Scholle; Mark D'Souza; Axel Bernal; Mark V Baev; Michael Farrell; Oleg V Kurnasov; Matthew D Daugherty; Faika Mseeh; Boris M Polanuyer; John W Campbell; Shubha Anantha; Konstantin Y Shatalin; Shamim A K Chowdhury; Michael Y Fonstein; Andrei L Osterman
Journal:  J Bacteriol       Date:  2002-08       Impact factor: 3.490

9.  Integration of the pSLT Plasmid into the Salmonella Chromosome Results in a Temperature-Sensitive Growth Defect Due to Aberrant DNA Replication.

Authors:  Christopher E Wozniak; Jordan J Hendriksen; Baldomero M Olivera; John R Roth; Kelly T Hughes
Journal:  J Bacteriol       Date:  2020-09-23       Impact factor: 3.490

10.  Identification of a repressor gene involved in the regulation of NAD de novo biosynthesis in Salmonella typhimurium.

Authors:  N Zhu; B M Olivera; J R Roth
Journal:  J Bacteriol       Date:  1988-01       Impact factor: 3.490
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.