| Literature DB >> 6305834 |
Abstract
The effects of the lymphokine, leukocyte inhibitory factor (LIF), on human neutrophil function were studied. This soluble mediator, which is defined by its specific inhibition of neutrophil locomotion, does not interfere with chemotactic factor binding and does not affect basal or stimulated superoxide generation by neutrophils. In contrast, phagocytosis of opsonized Staphylococcus aureus is markedly inhibited by LIF, and degranulation is stimulated by this lymphokine. The possible mechanisms of LIF action on neutrophils are discussed.Entities:
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Year: 1983 PMID: 6305834 DOI: 10.1007/bf00917819
Source DB: PubMed Journal: Inflammation ISSN: 0360-3997 Impact factor: 4.092