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Literature DB >> 6305543

Autoantibodies to liver-specific lipoprotein following hepatitis induced by mouse cytomegalovirus.

W N Bartholomaeus, G R Shellam, J E Allan, W D Reed, R A Joske.

Abstract

Autoantibodies to liver specific lipoprotein (LSP) are produced following acute non-fatal hepatitis in murine cytomegalovirus (MCMV) infected mice. Both C57B1 and BALB/c mice produced a transient LSP autoantibody response demonstrated by passive haemagglutination and enzyme linked immunosorbent assay. C57Bl mice produced both IgM and IgG LSP autoantibody and BALB/c mice produced only IgM autoantibody. The autoantibody was species non-specific, reacting with both mouse and rabbit LSP. Plasma containing LSP autoantibody reacted with the surface of normal mouse hepatocytes by immunofluorescence. This model provides an opportunity for study of LSP autoantibody production during viral hepatitis.

Entities: Disease Species

Mesh：

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Year: 1983 PMID： 6305543 PMCID： PMC1535580

Source DB: PubMed Journal: Clin Exp Immunol ISSN： 0009-9104 Impact factor: 4.330

20 in total

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11 in total

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Authors: Muhammed Yüksel; Debby Laukens; Femke Heindryckx; Hans Van Vlierberghe; Anja Geerts; F Susan Wong; Li Wen; Isabelle Colle
Journal: Int J Exp Pathol Date: 2014-08-12 Impact factor: 1.925

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Journal: Clin Exp Immunol Date: 1984-03 Impact factor: 4.330

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Authors: W N Bartholomaeus; W D Reed; R A Joske
Journal: Clin Exp Immunol Date: 1984-11 Impact factor: 4.330