Literature DB >> 6305356

Elemental sulfur: a novel inhibitor of adenylate kinase.

J Conner, P J Russell.   

Abstract

Elementary sulfur (S-8) is a novel, highly specific and potent inhibitor of adenylate kinase (AK). The inhibition of AK by S-8 is completely reversed by dithiothreitol and is accompanied by several fold increases in enzymatic activity. Sulfhydryl group interaction with S-8 does not appear to be the mechanism of AK inhibitor and the results of comparative inhibition studies with N-ethyl maleimide (NEM) indicates that NEM also does not interact with the sulfhydryl group of AK.

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Year:  1983        PMID： 6305356     DOI： 10.1016/0006-291x(83)90472-2

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  7 in total

1.  Energetic communication between mitochondria and nucleus directed by catalyzed phosphotransfer.

Authors:  Petras P Dzeja; Ryan Bortolon; Carmen Perez-Terzic; Ekshon L Holmuhamedov; Andre Terzic
Journal:  Proc Natl Acad Sci U S A       Date:  2002-07-15       Impact factor: 11.205

Review 2.  Sulphane sulphur in biological systems: a possible regulatory role.

Authors:  J I Toohey
Journal:  Biochem J       Date:  1989-12-15       Impact factor: 3.857

Review 3.  Chemical foundations of hydrogen sulfide biology.

Authors:  Qian Li; Jack R Lancaster
Journal:  Nitric Oxide       Date:  2013-07-09       Impact factor: 4.427

4.  Modification of erythrocyte enzyme activities by persulfides and methanethiol: possible regulatory role.

Authors:  W N Valentine; J I Toohey; D E Paglia; M Nakatani; R A Brockway
Journal:  Proc Natl Acad Sci U S A       Date:  1987-03       Impact factor: 11.205

Review 5.  Hydrogen sulfide and polysulfides as signaling molecules.

Authors:  Hideo Kimura
Journal:  Proc Jpn Acad Ser B Phys Biol Sci       Date:  2015       Impact factor: 3.493

6.  Identification of H2S3 and H2S produced by 3-mercaptopyruvate sulfurtransferase in the brain.

Authors:  Yuka Kimura; Yukiko Toyofuku; Shin Koike; Norihiro Shibuya; Noriyuki Nagahara; David Lefer; Yuki Ogasawara; Hideo Kimura
Journal:  Sci Rep       Date:  2015-10-06       Impact factor: 4.379

7.  Differential expression of adenine nucleotide converting enzymes in mitochondrial intermembrane space: a potential role of adenylate kinase isozyme 2 in neutrophil differentiation.

Authors:  Ayako Tanimura; Taigo Horiguchi; Keiko Miyoshi; Hiroko Hagita; Takafumi Noma
Journal:  PLoS One       Date:  2014-02-25       Impact factor: 3.240
  7 in total

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