| Literature DB >> 6305240 |
Abstract
The effect of endotoxin on serum levels of angiotensin-converting enzyme (ACE) in mice was studied. At a dose of 0.5 mg/kg intraperitoneally administered, endotoxin from Escherichia coli and Serratia marcescens lowered serum ACE. The effect of E. coli endotoxin on serum ACE can be demonstrated by 2 h, it returns to control values in 24 h, and is not dose-dependent in the 0.5 to 8.0 mg/kg range. The reduction of mouse serum ACE by parenteral endotoxin mimics the lower serum ACE observed in patients with gram-negative sepsis.Entities:
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Year: 1983 PMID： 6305240 DOI： 10.1164/arrd.1983.127.6.756
Source DB: PubMed Journal: Am Rev Respir Dis ISSN： 0003-0805