[Gilles de la Tourette's disease].

The case of a seventeen-year-old girl in whom typical particularly disabling Gilles de la Tourette syndrome had developed three years earlier is reported. The usual therapeutic agents (benzodiazepines, clomethiazole, paraldehyde, choline chloride) had proved totally or partially ineffective. Under 300 mg of tiapride per day given intramuscularly, the hyperkinesia and phonatory tics resolved rapidly. Conversion to a daily dosage of 900 mg of tiapride given orally ensured the permanence of this improvement and the patient was able to resume a nearly normal life.