Literature DB >> 6304879

Metabolism of polycyclic aromatic hydrocarbon derivatives to ultimate carcinogens during lipid peroxidation.

T A Dix, L J Marnett.   

Abstract

Lipid peroxidation triggered by ascorbate or reduced nicotinamide adenine dinucleotide in rat liver microsomes can initiate the epoxidation of 7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene. The stereochemistry of epoxidation is indicative of a peroxide-dependent free radical process. Since the epoxides formed may be the most carcinogenic derivatives of benzo[a]pyrene yet identified, lipid peroxidation can effect the metabolic activation of proximate carcinogens to ultimate carcinogens.

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Year:  1983        PMID： 6304879     DOI： 10.1126/science.6304879

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  16 in total

Review 1.  The molecular etiology and prevention of estrogen-initiated cancers: Ockham's Razor: Pluralitas non est ponenda sine necessitate. Plurality should not be posited without necessity.

Authors:  Ercole Cavalieri; Eleanor Rogan
Journal:  Mol Aspects Med       Date:  2013-08-30

Review 2.  The role of antioxidants and pro-oxidants in colon cancer.

Authors:  William L Stone; Koyamangalath Krishnan; Sharon E Campbell; Victoria E Palau
Journal:  World J Gastrointest Oncol       Date:  2014-03-15

3.  Production of reactive oxygen metabolites induced by asbestos fibres in human polymorphonuclear leucocytes.

Authors:  M Hedenborg; M Klockars
Journal:  J Clin Pathol       Date:  1987-10       Impact factor: 3.411

4.  Asbestos-catalysed lipid peroxidation and its inhibition by desferroxamine.

Authors:  S A Weitzman; A B Weitberg
Journal:  Biochem J       Date:  1985-01-01       Impact factor: 3.857

Review 5.  Free-radical mechanisms in tissue injury.

Authors:  T F Slater
Journal:  Biochem J       Date:  1984-08-15       Impact factor: 3.857

Review 6.  Tobacco use and cessation among women: research and treatment-related issues.

Authors:  Shiva D Rahmanian; Philip T Diaz; Mary Ellen Wewers
Journal:  J Womens Health (Larchmt)       Date:  2011-03       Impact factor: 2.681

7.  Bile salt stimulation of colonic epithelial proliferation. Evidence for involvement of lipoxygenase products.

Authors:  F R DeRubertis; P A Craven; R Saito
Journal:  J Clin Invest       Date:  1984-11       Impact factor: 14.808

8.  Fatty acid hydroperoxides support cytochrome P450 2S1-mediated bioactivation of benzo[a]pyrene-7,8-dihydrodiol.

Authors:  Peter H Bui; Erin L Hsu; Oliver Hankinson
Journal:  Mol Pharmacol       Date:  2009-08-27       Impact factor: 4.436

9.  Epoxidation of (+/-)-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene during (bi)sulfite autoxidation: activation of a procarcinogen by a cocarcinogen.

Authors:  G A Reed; J F Curtis; C Mottley; T E Eling; R P Mason
Journal:  Proc Natl Acad Sci U S A       Date:  1986-10       Impact factor: 11.205

10.  Clastogenic action of hydroperoxy-5,8,11,13-icosatetraenoic acids on the mouse embryo fibroblasts C3H/10T1/2.

Authors:  T Ochi; P A Cerutti
Journal:  Proc Natl Acad Sci U S A       Date:  1987-02       Impact factor: 11.205
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