Literature DB >> 6304818

Synthetic leukotriene B4 is a potent chemotaxin but a weak secretagogue for human PMN.

T E Rollins, B Zanolari, M S Springer, Y Guindon, R Zamboni, C K Lau, J Rokach.   

Abstract

We have examined the effects of very pure (greater than 99.8%) chemically synthesized leukotriene B4 of verified structure on the chemotactic and secretory behavior of human polymorphonuclear leukocytes (PMN). The synthetic material is highly chemotactic and shows the same concentration dependence of this activity as does natural LTB4. Synthetic LTB4 is also a weak degranulating agent in cytochalasin B treated PMN. Maximally it released 11%, 17% and 26% as much N-acetyl-beta-D-glucosaminidase, myeloperoxidase and lysozyme as did N-formyl-methionine-leucine-phenylalanine (fMLP). Thus LTB4 differs significantly from other chemotaxins, such as C5a and fMLP, in that it is a poor secretagogue for enzymes of the specific and azurophilic granules of human PMN.

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Year:  1983        PMID： 6304818     DOI： 10.1016/0090-6980(83)90110-7

Source DB:  PubMed          Journal:  Prostaglandins        ISSN： 0090-6980


  11 in total

1.  Effect of inhaled leukotriene B4 alone and in combination with prostaglandin D2 on bronchial responsiveness to histamine in normal subjects.

Authors:  P N Black; R W Fuller; G W Taylor; P J Barnes; C T Dollery
Journal:  Thorax       Date:  1989-06       Impact factor: 9.139

2.  Evidence that activation of a common G-protein by receptors for leukotriene B4 and N-formylmethionyl-leucyl-phenylalanine in HL-60 cells occurs by different mechanisms.

Authors:  K R McLeish; P Gierschik; T Schepers; D Sidiropoulos; K H Jakobs
Journal:  Biochem J       Date:  1989-06-01       Impact factor: 3.857

Review 3.  Leukotrienes in inflammation.

Authors:  M A Bray
Journal:  Agents Actions       Date:  1986-10

4.  2-substituted indazolinones: orally active and selective 5-lipoxygenase inhibitors with anti-inflammatory activity.

Authors:  S J Foster; P Bruneau; E R Walker; R M McMillan
Journal:  Br J Pharmacol       Date:  1990-01       Impact factor: 8.739

5.  Remarkable elevation of leukotriene B4 in rat skin after induction of UV photodermatitis.

Authors:  H Nakaguma; H Takahashi
Journal:  Inflammation       Date:  1990-04       Impact factor: 4.092

6.  In vitro effects of leukotriene B4 (LTB4) on canine PMN effector function(s).

Authors:  D F Gruber; M M D'Alesandro; T L Walden
Journal:  Agents Actions       Date:  1989-11

7.  Effects of leukotriene B4 in the human lung. Recruitment of neutrophils into the alveolar spaces without a change in protein permeability.

Authors:  T R Martin; B P Pistorese; E Y Chi; R B Goodman; M A Matthay
Journal:  J Clin Invest       Date:  1989-11       Impact factor: 14.808

8.  Leukotriene C4 uses a probenecid-sensitive export carrier that does not recognize leukotriene B4.

Authors:  B K Lam; K Xu; M B Atkins; K F Austen
Journal:  Proc Natl Acad Sci U S A       Date:  1992-12-01       Impact factor: 11.205

9.  Molecular cloning and expression of human leukotriene-C4 synthase.

Authors:  D J Welsch; D P Creely; S D Hauser; K J Mathis; G G Krivi; P C Isakson
Journal:  Proc Natl Acad Sci U S A       Date:  1994-10-11       Impact factor: 11.205

10.  Differential cholera-toxin- and pertussis-toxin-catalysed ADP-ribosylation of G-proteins coupled to formyl-peptide and leukotriene B4 receptors.

Authors:  T M Schepers; K R McLeish
Journal:  Biochem J       Date:  1993-01-15       Impact factor: 3.857
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