| Literature DB >> 6304535 |
Abstract
Three 8-base pair (bp) segments of alternating purine-pyrimidine from the simian virus 40 enhancer region form Z-DNA on negative supercoiling; minichromosome DNase I-hypersensitive sites determined by others bracket these three segments. A survey of transcriptional enhancer sequences reveals a pattern of potential Z-DNA-forming regions which occur in pairs 50-80 bp apart. This may influence local chromatin structure and may be related to transcriptional activation.Entities:
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Year: 1983 PMID: 6304535 DOI: 10.1038/303674a0
Source DB: PubMed Journal: Nature ISSN: 0028-0836 Impact factor: 49.962