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Literature DB >> 6304531

Growth of chromosome ends in multiplying trypanosomes.

A Bernards, P A Michels, C R Lincke, P Borst.

Abstract

Some of the genes for the variant surface glycoproteins of trypanosomes are located close to a discontinuity in the DNA, presumably a chromosome end. We show here that DNA fragments containing these telomeres increase in length in multiplying trypanosomes at a rate of about 10 base pairs per division. We argue that chromosome growth may not be restricted to trypanosomes and could explain the heterogeneity of telomeric DNA fragments observed in some other organisms.

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Year: 1983 PMID： 6304531 DOI： 10.1038/303592a0

Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962

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Cited

82 in total

1. More surprises from Kinetoplastida.

Authors: J E Donelson; M J Gardner; N M El-Sayed
Journal: Proc Natl Acad Sci U S A Date: 1999-03-16 Impact factor: 11.205

2. A central role for Plasmodium falciparum subtelomeric regions in spatial positioning and telomere length regulation.

Authors: Luisa M Figueiredo; Lúcio H Freitas-Junior; Emmanuel Bottius; Jean-Christophe Olivo-Marin; Artur Scherf
Journal: EMBO J Date: 2002-02-15 Impact factor: 11.598

3. RAD50 and RAD51 define two pathways that collaborate to maintain telomeres in the absence of telomerase.

Authors: S Le; J K Moore; J E Haber; C W Greider
Journal: Genetics Date: 1999-05 Impact factor: 4.562

4. Modulation of telomere length dynamics by the subtelomeric region of tetrahymena telomeres.

Authors: Naduparambil K Jacob; Angela R Stout; Carolyn M Price
Journal: Mol Biol Cell Date: 2004-05-28 Impact factor: 4.138

5. Chromosome structure: DNA nucleotide sequence elements of a subset of the minichromosomes of the protozoan Trypanosoma brucei.

Authors: M Weiden; Y N Osheim; A L Beyer; L H Van der Ploeg
Journal: Mol Cell Biol Date: 1991-08 Impact factor: 4.272

6. Biological variation among african trypanosomes: I. Clonal expression of virulence is not linked to the variant surface glycoprotein or the variant surface glycoprotein gene telomeric expression site.

Authors: Jill A Inverso; Timothy S Uphoff; Scott C Johnson; Donna M Paulnock; John M Mansfield
Journal: DNA Cell Biol Date: 2010-05 Impact factor: 3.311

Growth of chromosome ends in multiplying trypanosomes.

1. More surprises from Kinetoplastida.

2. A central role for Plasmodium falciparum subtelomeric regions in spatial positioning and telomere length regulation.

3. RAD50 and RAD51 define two pathways that collaborate to maintain telomeres in the absence of telomerase.

4. Modulation of telomere length dynamics by the subtelomeric region of tetrahymena telomeres.

5. Chromosome structure: DNA nucleotide sequence elements of a subset of the minichromosomes of the protozoan Trypanosoma brucei.

6. Biological variation among african trypanosomes: I. Clonal expression of virulence is not linked to the variant surface glycoprotein or the variant surface glycoprotein gene telomeric expression site.

7. The telomeric GGGTTA repeats of Trypanosoma brucei contain the hypermodified base J in both strands.

Review 8. The central roles of telomeres and subtelomeres in antigenic variation in African trypanosomes.

9. Consequences of telomere shortening at an active VSG expression site in telomerase-deficient Trypanosoma brucei.

10. The Saccharomyces cerevisiae chromosome III left telomere has a type X, but not a type Y', ARS region.