Literature DB >> 6303339

Anti-mutagenic chalcones: antagonizing the mutagenicity of benzo(a)pyrene on Salmonella typhimurium.

T Torigoe, M Arisawa, S Itoh, M Fujiu, H B Maruyama.   

Abstract

Several chalcone derivatives; e.g. Ro 09-0204, Ro 09-0323 and Ro 09-0501 were found to reduce markedly the revertant increase of Salmonella typhimurium TA100 by benzo(a)pyrene during the incubation with S-9 Mix. The antimutagenic activity was 100 - 700 times stronger than that of L-ascorbic acid. Effect on other mutagens, the structure activity relationship and the possible mechanism of action are briefly discussed.

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Year:  1983        PMID： 6303339     DOI： 10.1016/0006-291x(83)91693-5

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  6 in total

1.  Novel chalcone derivatives as potent Nrf2 activators in mice and human lung epithelial cells.

Authors:  Vineet Kumar; Sarvesh Kumar; Mohammad Hassan; Hailong Wu; Rajesh K Thimmulappa; Amit Kumar; Sunil K Sharma; Virinder S Parmar; Shyam Biswal; Sanjay V Malhotra
Journal:  J Med Chem       Date:  2011-05-19       Impact factor: 7.446

2.  Effect of turmeric on xenobiotic metabolising enzymes.

Authors:  V K Goud; K Polasa; K Krishnaswamy
Journal:  Plant Foods Hum Nutr       Date:  1993-07       Impact factor: 3.921

3.  Absence of genotoxic effects of the chalcone (E)-1-(2-hydroxyphenyl)-3-(4-methylphenyl)-prop-2-en-1-one) and its potential chemoprevention against DNA damage using in vitro and in vivo assays.

Authors:  Débora Cristina da Silva Lima; Camila Regina do Vale; Jefferson Hollanda Véras; Aline Bernardes; Caridad Noda Pérez; Lee Chen-Chen
Journal:  PLoS One       Date:  2017-02-16       Impact factor: 3.240

4.  4-Hydroxyhalcone effects on cisplatin-induced genotoxicity model.

Authors:  Aref Nazari; Mina Mirian; Mahmoud Aghaei; Mehdi Aliomrani
Journal:  Toxicol Res (Camb)       Date:  2021-01-05       Impact factor: 3.524

5.  Structural antitumoral activity relationships of synthetic chalcones.

Authors:  Cesar Echeverria; Juan Francisco Santibañez; Oscar Donoso-Tauda; Carlos A Escobar; Rodrigo Ramirez-Tagle
Journal:  Int J Mol Sci       Date:  2009-01-09       Impact factor: 6.208

6.  Genotoxic, Cytotoxic, Antigenotoxic, and Anticytotoxic Effects of Sulfonamide Chalcone Using the Ames Test and the Mouse Bone Marrow Micronucleus Test.

Authors:  Carolina Ribeiro E Silva; Flávio Fernandes Veloso Borges; Aline Bernardes; Caridad Noda Perez; Daniela de Melo E Silva; Lee Chen-Chen
Journal:  PLoS One       Date:  2015-09-03       Impact factor: 3.240
  6 in total

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