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Literature DB >> 6302847

Potassium currents in Drosophila: different components affected by mutations of two genes.

C F Wu, B Ganetzky, F N Haugland, A X Liu.

Abstract

Electrophysiological analysis of the Drosophila behavioral mutants Eag and Sh and the double mutant Eag Sh indicates that the products of both genes take part in the control of potassium currents in the membranes of both nerve and muscle. In voltage-clamped larval muscle fibers, Sh affects the transient A current, whereas Eag reduces the delayed rectification and, to a lesser extent, the A current.

Entities: Chemical Gene Species

Mesh：

Substances：
Ion Channels
Potassium

Year: 1983 PMID： 6302847 DOI： 10.1126/science.6302847

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

54 in total

1. Unmasking of a novel potassium current in Drosophila by a mutation and drugs.

Authors: A Singh; S Singh
Journal: J Neurosci Date: 1999-08-15 Impact factor: 6.167

2. Sh and eag K(+) channel subunit interaction in frog oocytes depends on level and time of expression.

Authors: M L Chen; T Hoshi; C F Wu
Journal: Biophys J Date: 2000-09 Impact factor: 4.033

3. A novel leg-shaking Drosophila mutant defective in a voltage-gated K(+)current and hypersensitive to reactive oxygen species.

Authors: J W Wang; J M Humphreys; J P Phillips; A J Hilliker; C F Wu
Journal: J Neurosci Date: 2000-08-15 Impact factor: 6.167

4. Interactions of membrane excitability mutations affecting potassium and sodium currents in the flight and giant fiber escape systems of Drosophila.

Authors: J E Engel; C F Wu
Journal: J Comp Physiol A Date: 1992-08 Impact factor: 1.836

Potassium currents in Drosophila: different components affected by mutations of two genes.

1. Unmasking of a novel potassium current in Drosophila by a mutation and drugs.

2. Sh and eag K(+) channel subunit interaction in frog oocytes depends on level and time of expression.

3. A novel leg-shaking Drosophila mutant defective in a voltage-gated K(+)current and hypersensitive to reactive oxygen species.

4. Interactions of membrane excitability mutations affecting potassium and sodium currents in the flight and giant fiber escape systems of Drosophila.

5. Neuronal activity and adenylyl cyclase in environment-dependent plasticity of axonal outgrowth in Drosophila.

6. Neuropathology in Drosophila membrane excitability mutants.

7. Properties of potassium channels altered by mutations of two genes in Drosophila.

Review 8. The purification of ion channels from excitable cells.

Review 9. New approaches for studying synaptic development, function, and plasticity using Drosophila as a model system.

10. Dosage effects of a Drosophila sodium channel gene on behavior and axonal excitability.