Literature DB >> 6302840

Amiloride directly inhibits the Na,K-ATPase activity of rabbit kidney proximal tubules.

S P Soltoff, L J Mandel.   

Abstract

Amiloride inhibited the ouabain-sensitive rate of oxygen consumption (QO2) of a suspension of rabbit intact proximal tubules in the presence of different concentrations of extracellular sodium. Measurements of the ouabain-sensitive QO2 in the presence of nystatin, the tissue sodium and potassium contents of the tubules in suspension, and the sodium- and potassium-dependent adenosinetriphosphatase (Na,K-ATPase) activity of lysed tubule membranes indicated that the effect of amiloride was due to a direct inhibition of the Na,K-ATPase activity of the proximal tubule.

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Year:  1983        PMID： 6302840     DOI： 10.1126/science.6302840

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  33 in total

1.  Characterization of transport Na(+)-ATPases in gills of freshwater tilapia : Evidence for branchial Na(+)/H (+) (-NH4 (+)), ATPase activity in fish gills.

Authors:  P Balm; N Goossen; S van de Rijke; S W Bonga
Journal:  Fish Physiol Biochem       Date:  1988-03       Impact factor: 2.794

2.  Regulation of intracellular sodium and pH by the electrogenic H+ pump in frog skin.

Authors:  B J Harvey; J Ehrenfeld
Journal:  Pflugers Arch       Date:  1986-04       Impact factor: 3.657

3.  Ba2+ and amiloride uncover or induce a pH-sensitive and a Na+ or non-selective cation conductance in transitional cells of the inner ear.

Authors:  P Wangemann; N Shiga
Journal:  Pflugers Arch       Date:  1994-02       Impact factor: 3.657

4.  Inhibition of neuronal noradrenaline transport (uptake1) and desipramine binding by amiloride and ethylisopropylamiloride.

Authors:  E Schömig; J Michael-Hepp; C L Schönfeld
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1989-11       Impact factor: 3.000

5.  Mechanism of aldosterone-induced increase of K+ conductance in early distal renal tubule cells of the frog.

Authors:  W H Wang; R M Henderson; J Geibel; S White; G Giebisch
Journal:  J Membr Biol       Date:  1989-11       Impact factor: 1.843

6.  Effects of amiloride analogues on the production of prostacyclin by aortic endothelial cells.

Authors:  J M Boeynaems; D Demolle; C Lagneau; E J Cragoe
Journal:  Br J Pharmacol       Date:  1989-11       Impact factor: 8.739

7.  Involvement of the Na,K-ATPase in the induction of ion channels by palytoxin.

Authors:  S Y Kim; K A Marx; C H Wu
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1995-05       Impact factor: 3.000

8.  A unique modulator of endoplasmic reticulum stress-signalling pathways: the novel pharmacological properties of amiloride in glial cells.

Authors:  Toru Hosoi; Ayaka Kume; Kayo Otani; Tatsuya Oba; Koichiro Ozawa
Journal:  Br J Pharmacol       Date:  2009-12-15       Impact factor: 8.739

9.  Amiloride reduces the taste intensity of Na+ and Li+ salts and sweeteners.

Authors:  S S Schiffman; E Lockhead; F W Maes
Journal:  Proc Natl Acad Sci U S A       Date:  1983-10       Impact factor: 11.205

10.  Millimolar amiloride concentrations block K conductance in proximal tubular cells.

Authors:  F Discala; P Hulin; F Belachgar; G Planelles; A Edelman; T Anagnostopoulos
Journal:  Br J Pharmacol       Date:  1992-10       Impact factor: 8.739
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