Literature DB >> 6302709

Effect of chronic hypoxia on angiotensin-induced pulmonary vasoconstriction and converting enzyme activity in the rat.

R W Caldwell, C M Blatteis.   

Abstract

Rats were exposed to high-altitude (5500 m) hypoxia for 2 weeks. On examination 1-3 days after return to sea level and compared with control rats, they exhibited pulmonary hypertension, reduced angiotensin-converting enzyme activity, greater vascular responsiveness to angiotensin II (AII), and resistance to blockade of AII pulmonary pressor responses by the AII antagonist, saralasin.

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Year:  1983        PMID： 6302709     DOI： 10.3181/00379727-172-41568

Source DB:  PubMed          Journal:  Proc Soc Exp Biol Med        ISSN： 0037-9727


  4 in total

1.  Angiotensin II receptor expression and inhibition in the chronically hypoxic rat lung.

Authors:  L Zhao; R al-Tubuly; A Sebkhi; A A Owji; D J Nunez; M R Wilkins
Journal:  Br J Pharmacol       Date:  1996-11       Impact factor: 8.739

2.  Lung angiotensin converting enzyme activity in rats with differing susceptibilities to chronic hypoxia.

Authors:  P Jederlinic; N S Hill; L C Ou; B L Fanburg
Journal:  Thorax       Date:  1988-09       Impact factor: 9.139

3.  Lung angiotensin converting enzyme activity in chronically hypoxic rats.

Authors:  J M Kay; P M Keane; K L Suyama; D Gauthier
Journal:  Thorax       Date:  1985-08       Impact factor: 9.139

4.  Angiotensin converting enzyme expression is increased in small pulmonary arteries of rats with hypoxia-induced pulmonary hypertension.

Authors:  N W Morrell; E N Atochina; K G Morris; S M Danilov; K R Stenmark
Journal:  J Clin Invest       Date:  1995-10       Impact factor: 14.808
  4 in total

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