Literature DB >> 6302592

Trifluoperazine inhibits hippocampal long-term potentiation and the phosphorylation of a 40,000 dalton protein.

R C Finn, M Browning, G Lynch.   

Abstract

Brief high frequency stimulation induces long-term potentiation (LTP) and changes in the endogenous phosphorylation of a 40,000 dalton protein in the hippocampus in a calcium-dependent manner. In the present paper we report that 40 microM trifluoperazine (TFP), a phenothiazine that binds calmodulin and blocks its activity, inhibits LTP in the hippocampal slice. In addition, calmodulin stimulates and TFP inhibits the phosphorylation of the 40,000 dalton protein (as well as that of several other proteins) in a dose-dependent fashion.

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Year:  1980        PMID： 6302592     DOI： 10.1016/0304-3940(80)90264-5

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  10 in total

1.  Calmodulin blockers decrease short-term plasticity of the cholinoreceptors of neurons of the edible snail.

Authors:  A S Pivovarov; E I Drozdova; B I Kotlyar
Journal:  Neurosci Behav Physiol       Date:  1991 Jul-Aug

Review 2.  Molecular mechanisms of neuronal plasticity during learning: the role of secondary messengers.

Authors:  B I Kotlyar; A S Pivovarov
Journal:  Neurosci Behav Physiol       Date:  1990 Mar-Apr

Review 3.  Calcium/calmodulin-dependent protein kinase II.

Authors:  R J Colbran; C M Schworer; Y Hashimoto; Y L Fong; D P Rich; M K Smith; T R Soderling
Journal:  Biochem J       Date:  1989-03-01       Impact factor: 3.857

Review 4.  A molecular description of nerve terminal function.

Authors:  L F Reichardt; R B Kelly
Journal:  Annu Rev Biochem       Date:  1983       Impact factor: 23.643

5.  Long-term potentiation induced by a sustained rise in the intraterminal Ca2+ in bull-frog sympathetic ganglia.

Authors:  S Minota; E Kumamoto; O Kitakoga; K Kuba
Journal:  J Physiol       Date:  1991-04       Impact factor: 5.182

6.  Mechanisms of the development of sensitizations in the snail: the participation of calcium and calmodulin.

Authors:  V P Nikitin; M O Samoilov; S A Kozyrev
Journal:  Neurosci Behav Physiol       Date:  1994 Jan-Feb

Review 7.  Hippocampal glutamate receptors.

Authors:  M Baudry; G Lynch
Journal:  Mol Cell Biochem       Date:  1981-08-11       Impact factor: 3.396

8.  Ca2+/calmodulin-dependent protein kinase II phosphorylation of the presynaptic protein synapsin I is persistently increased during long-term potentiation.

Authors:  A S Nayak; C I Moore; M D Browning
Journal:  Proc Natl Acad Sci U S A       Date:  1996-12-24       Impact factor: 11.205

9.  Protein synthesis inhibition blocks the induction of mossy fiber long-term potentiation in vivo.

Authors:  E J Barea-Rodríguez; D T Rivera; D B Jaffe; J L Martinez
Journal:  J Neurosci       Date:  2000-11-15       Impact factor: 6.167

Review 10.  Effects of antipsychotic D2 antagonists on long-term potentiation in animals and implications for human studies.

Authors:  Rae Price; Bahar Salavati; Ariel Graff-Guerrero; Daniel M Blumberger; Benoit H Mulsant; Zafiris J Daskalakis; Tarek K Rajji
Journal:  Prog Neuropsychopharmacol Biol Psychiatry       Date:  2014-05-10       Impact factor: 5.067
  10 in total

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