Literature DB >> 6302012

Neutrophil aggregating properties of PAF-acether and leukotriene B4.

A W Ford-Hutchinson.   

Abstract

Both leukotriene B4 (LTB4) and platelet activating factor (PAF-acether) induce the aggregation of rat polymorphonuclear leucocytes. PAF-acether, but not LTB4, causes the aggregation of washed rabbit platelets. The results obtained from cross-desensitisation studies and experiments using inhibitors of arachidonic acid metabolism support the concept that LTB4 and PAF-acether have separate receptor sites on the neutrophil cell surface and show that PAF-acether does not induce neutrophil aggregation by releasing LTB4.

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Year:  1983        PMID： 6302012     DOI： 10.1016/0192-0561(83)90067-x

Source DB:  PubMed          Journal:  Int J Immunopharmacol        ISSN： 0192-0561


  7 in total

1.  Inflammatory signaling in NEC: Role of NF-κB, cytokines and other inflammatory mediators.

Authors:  Catherine J Hunter; Isabelle G De Plaen
Journal:  Pathophysiology       Date:  2013-12-31

2.  Nonsteroidal antiinflammatory drugs exert differential effects on neutrophil function and plasma membrane viscosity. Studies in human neutrophils and liposomes.

Authors:  S B Abramson; B Cherksey; D Gude; J Leszczynska-Piziak; M R Philips; L Blau; G Weissmann
Journal:  Inflammation       Date:  1990-02       Impact factor: 4.092

Review 3.  Inflammatory signaling in necrotizing enterocolitis.

Authors:  Isabelle G De Plaen
Journal:  Clin Perinatol       Date:  2013-01-17       Impact factor: 3.430

4.  Role of neutrophils in gastric damage induced by platelet activating factor.

Authors:  A Etienne; F Thonier; F Hecquet; P Braquet
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1988-10       Impact factor: 3.000

5.  Modulation of formation of tumor metastases by peritoneal macrophages elicited by various agents.

Authors:  E Gorelik; R H Wiltrout; D Copeland; R B Herberman
Journal:  Cancer Immunol Immunother       Date:  1985       Impact factor: 6.968

6.  Platelet-activating factor-induced hydrolysis of phosphatidylinositol 4,5-bisphosphate stimulates the production of reactive oxygen intermediates in macrophages.

Authors:  S J Huang; P N Monk; C P Downes; A D Whetton
Journal:  Biochem J       Date:  1988-02-01       Impact factor: 3.857

7.  Modes of action of aspirin-like drugs.

Authors:  S Abramson; H Korchak; R Ludewig; H Edelson; K Haines; R I Levin; R Herman; L Rider; S Kimmel; G Weissmann
Journal:  Proc Natl Acad Sci U S A       Date:  1985-11       Impact factor: 11.205
  7 in total

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