Literature DB >> 6301876

Amino acid sequence around the active site cysteine residue of calcium-activated neutral protease (CANP).

K Suzuki, H Hayashi, T Hayashi, K Iwai.   

Abstract

The active site of calcium-activated neutral protease (CANP) was specifically labeled with iodoacetic acid. The active site hepta peptide was isolated from carboxymethylated CANP after digestion with proteases and the sequence was determined. The sequence indicates that CANP is a thiol protease and its comparison with other thiol proteases is described.

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Year:  1983        PMID： 6301876     DOI： 10.1016/0014-5793(83)80483-9

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  6 in total

1.  Design, synthesis, and optimization of novel epoxide incorporating peptidomimetics as selective calpain inhibitors.

Authors:  Isaac T Schiefer; Subhasish Tapadar; Vladislav Litosh; Marton Siklos; Rob Scism; Gihani T Wijewickrama; Esala P Chandrasena; Vaishali Sinha; Ehsan Tavassoli; Michael Brunsteiner; Mauro Fa'; Ottavio Arancio; Pavel Petukhov; Gregory R J Thatcher
Journal:  J Med Chem       Date:  2013-07-22       Impact factor: 7.446

2.  Interaction of aspartic acid-104 and proline-287 with the active site of m-calpain.

Authors:  J S Arthur; J S Elce
Journal:  Biochem J       Date:  1996-10-15       Impact factor: 3.857

3.  Catalytic-site characteristics of the porcine calpain II 80 kDa/18 kDa heterodimer revealed by selective reaction of its essential thiol group with two-hydronic-state time-dependent inhibitors: evidence for a catalytic site Cys/His interactive system and an ionizing modulatory group.

Authors:  G W Mellor; S K Sreedharan; D Kowlessur; E W Thomas; K Brocklehurst
Journal:  Biochem J       Date:  1993-02-15       Impact factor: 3.857

Review 4.  Cysteine proteinases and metastasis.

Authors:  B F Sloane; K V Honn
Journal:  Cancer Metastasis Rev       Date:  1984       Impact factor: 9.264

5.  Calpain inhibition by peptide epoxides.

Authors:  C Parkes; A A Kembhavi; A J Barrett
Journal:  Biochem J       Date:  1985-09-01       Impact factor: 3.857

6.  p-Benzoquinone, a reactive metabolite of benzene, prevents the processing of pre-interleukins-1 alpha and -1 beta to active cytokines by inhibition of the processing enzymes, calpain, and interleukin-1 beta converting enzyme.

Authors:  G F Kalf; J F Renz; R Niculescu
Journal:  Environ Health Perspect       Date:  1996-12       Impact factor: 9.031
  6 in total

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