Literature DB >> 6301854

Chronic antidepressant treatment enhances agonist affinity of brain alpha 1-adrenoceptors.

D B Menkes, G K Aghajanian, D W Gallager.   

Abstract

Binding of [3H]prazosin, a selective alpha 1-adrenoceptor antagonist, to thalamic membranes was studied following chronic treatment of rats with tricyclic antidepressants. Rosenthal analysis showed no change in the number or affinity of antagonist binding sites; however, the ability of the alpha 1-agonist phenylephrine to compete for these sites was significantly enhanced after chronic tricyclic treatment. This result is consistent with previous studies showing physiological alpha 1-supersensitivity in thalamus after chronic antidepressant administration.

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Year:  1983        PMID： 6301854     DOI： 10.1016/0014-2999(83)90047-x

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  15 in total

Review 1.  Effects of long-term administration of antidepressants and neuroleptics on receptors in the central nervous system.

Authors:  G B Baker; A J Greenshaw
Journal:  Cell Mol Neurobiol       Date:  1989-03       Impact factor: 5.046

2.  Effect of repeated treatment with antidepressant drugs and electroconvulsive shock (ECS) on [3H] prazosin binding to different rat brain structures.

Authors:  G Nowak; E Przegaliński
Journal:  J Neural Transm       Date:  1988       Impact factor: 3.575

3.  The responsiveness of cerebral cortical adrenergic receptors after chronic administration of atypical antidepressant mianserin.

Authors:  I Nalepa; J Vetulani
Journal:  J Psychiatry Neurosci       Date:  1994-03       Impact factor: 6.186

4.  Noradrenaline-stimulated inositol phospholipid breakdown as a measure of alpha 1-adrenoceptor function in rat hippocampal miniprisms after repeated antidepressant treatment.

Authors:  C J Fowler; W Danysz; T Archer
Journal:  J Neural Transm       Date:  1986       Impact factor: 3.575

5.  Oxaprotiline enantiomers given repeatedly and brain alpha-adrenoceptors.

Authors:  J Maj; K Wedzony; V Klimek; Z Rogóz; G Skuz
Journal:  J Neural Transm Gen Sect       Date:  1990

6.  Effect of prenatal exposure to tianeptine on different neurotransmitter receptors and 5-HT-stimulated inositol phosphate formation in rat brain.

Authors:  G Romero; E Toscano; D Montero; M C De Felipe; J Del Rio
Journal:  J Neural Transm Gen Sect       Date:  1992

7.  Neuroendocrine response to clonidine and 8-OH-DPAT in rats following chronic administration of desipramine or sertraline.

Authors:  J M O'Donnell; M Grealy
Journal:  Br J Pharmacol       Date:  1992-04       Impact factor: 8.739

8.  Assessment of rat brain alpha 1-adrenoceptor binding and activation of inositol phospholipid turnover following chronic imipramine treatment.

Authors:  P P Li; J J Warsh; D Sibony; A Chiu
Journal:  Neurochem Res       Date:  1988-12       Impact factor: 3.996

9.  Lateral diffusion of Gαs in the plasma membrane is decreased after chronic but not acute antidepressant treatment: role of lipid raft and non-raft membrane microdomains.

Authors:  Andrew H Czysz; Jeffrey M Schappi; Mark M Rasenick
Journal:  Neuropsychopharmacology       Date:  2014-09-24       Impact factor: 7.853

10.  Effect of chronic lithium administration on adrenoceptor binding and adrenoceptor regulation in rat cerebral cortex.

Authors:  G Gross; C Dodt; G Hanft
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1988-03       Impact factor: 3.000
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