Literature DB >> 6301493

Presence of VIP receptors in a human pancreatic adenocarcinoma cell line. Modulation of the cAMP response during cell proliferation.

A Estival, P Mouniélou, V Trocheris, J L Scemama, F Clemente, E Hollande, A Ribet.   

Abstract

It is known that the human exocrine pancreas responds to secretin stimulation more than does VIP, a structurally related peptide. We looked for the receptors for those polypeptides in a human pancreatic cancer cell line grown in culture and in nude mice. By analysing the cAMP responses and the 125I-VIP binding we found VIP receptors with a KD of 1.5 10(-9) M. Secretin stimulates the adenylate cyclase through the VIP receptor sites with a KD of 1.7. 10(-6) M. We noted also that during cell proliferation in culture there was about a 5 fold increase of the cAMP response to VIP.

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Year:  1983        PMID： 6301493     DOI： 10.1016/0006-291x(83)91393-1

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  11 in total

1.  Two subclasses of EGF receptors in the human pancreatic cancer cell lines CAPAN-1 and MIA PaCa-2.

Authors:  P Oustry; A Estival; L Pradayrol; N Vaysse; F Clémente
Journal:  Int J Pancreatol       Date:  1990-03

2.  Adenylate cyclase activity in human pancreatic adenocarcinoma cell lines.

Authors:  L al-Nakkash; N L Simmons; J M Lingard; B E Argent
Journal:  Int J Pancreatol       Date:  1996-02

3.  Cholecystokinin stimulates growth of human pancreatic adenocarcinoma SW-1990.

Authors:  J P Smith; T E Solomon; S Bagheri; S Kramer
Journal:  Dig Dis Sci       Date:  1990-11       Impact factor: 3.199

4.  Expression of peptide receptors in human endocrine tumours of the pancreas.

Authors:  C Tang; I Biemond; C B Lamers
Journal:  Gut       Date:  1997-02       Impact factor: 23.059

Review 5.  Hormonal therapy of pancreatic carcinoma. Rationale and perspectives.

Authors:  D Perilli; C Mansi; V Savarino; G Celle
Journal:  Int J Pancreatol       Date:  1993-06

6.  Comparative studies of the angiogenic activity of vasoactive intestinal peptide, endothelins-1 and -3 and angiotensin II in a rat sponge model.

Authors:  D E Hu; C R Hiley; T P Fan
Journal:  Br J Pharmacol       Date:  1996-02       Impact factor: 8.739

Review 7.  Gastrointestinal hormones as potential adjuvant treatment of exocrine pancreatic adenocarcinoma.

Authors:  W E Fisher; P Muscarella; L G Boros; W J Schirmer
Journal:  Int J Pancreatol       Date:  1998-12

8.  Phosphorylation-regulated low-conductance Cl- channels in a human pancreatic duct cell line.

Authors:  F Becq; E Hollande; M Gola
Journal:  Pflugers Arch       Date:  1993-10       Impact factor: 3.657

Review 9.  Biology of pancreatic cancer.

Authors:  G J Poston; J Gillespie; P J Guillou
Journal:  Gut       Date:  1991-07       Impact factor: 23.059

10.  Expression of receptors for gut peptides in human pancreatic adenocarcinoma and tumour-free pancreas.

Authors:  C Tang; I Biemond; G J Offerhaus; W Verspaget; C B Lamers
Journal:  Br J Cancer       Date:  1997       Impact factor: 7.640
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