Literature DB >> 6301356

Analysis of human erythrocyte 5'-nucleotidases in healthy individuals and a patient deficient in pyrimidine 5'-nucleotidase.

D M Swallow, I Aziz, D A Hopkinson, S Miwa.   

Abstract

Electrophoretic and quantitative analysis of pyrimidine 5'-nucleotidase in human erythrocytes from healthy individuals and a patient deficient in pyrimidine 5'-nucleotidase, using a range of substrates, has shown that the patient has a marked deficiency with UMP, CMP and dCMP as substrates but near normal levels of activity with dUMP and dTMP as substrates. The observations suggest that two separate structural gene loci coding for distinct 5'-nucleotidases with similar electrophoretic mobility exist in man. The genetic determination of these enzymes seems therefore to be homologous with that found in rodents.

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Year:  1983        PMID： 6301356     DOI： 10.1111/j.1469-1809.1983.tb00966.x

Source DB:  PubMed          Journal:  Ann Hum Genet        ISSN： 0003-4800            Impact factor:   1.670


  6 in total

1.  Identification of thymidine nucleotidase and deoxyribonucleotidase activities among normal isozymes of 5'-nucleotidase in human erythrocytes.

Authors:  D E Paglia; W N Valentine; R A Brockway
Journal:  Proc Natl Acad Sci U S A       Date:  1984-01       Impact factor: 11.205

2.  Pyrimidine 5'-nucleotidase activity in normal and deficient human lymphoblastoid cells.

Authors:  D A Hopkinson; D M Swallow; A Marinaki; E H Harley
Journal:  J Inherit Metab Dis       Date:  1990       Impact factor: 4.982

3.  Detection of pyrimidine 5'-nucleotidase deficiency using 1H- or 31P-nuclear magnetic resonance.

Authors:  T Kagimoto; K Shirono; T Higaki; T Oda; H Matsuzaki; K Nagata; T Nakaji; Y Morino; K Takatsuki
Journal:  Experientia       Date:  1986-01-15

4.  Homogeneous pyrimidine nucleotidase from human erythrocytes: enzymic and molecular properties.

Authors:  A Amici; M Emanuelli; E Ferretti; N Raffaelli; S Ruggieri; G Magni
Journal:  Biochem J       Date:  1994-12-15       Impact factor: 3.857

5.  5'-Nucleotidase activities in human erythrocytes. Identification of a purine 5'-nucleotidase stimulated by ATP and glycerate 2,3-bisphosphate.

Authors:  F Bontemps; G Van den Berghe; H G Hers
Journal:  Biochem J       Date:  1988-03-15       Impact factor: 3.857

6.  Why dentists don't use rubber dam during endodontics and how to promote its usage?

Authors:  Ahmad A Madarati
Journal:  BMC Oral Health       Date:  2016-02-25       Impact factor: 2.757
  6 in total

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