Literature DB >> 6301148

The effect of ammonium chloride and tunicamycin on the glycoprotein content and infectivity of herpes simplex virus type 1.

K G Kousoulas, D J Bzik, N DeLuca, S Person.   

Abstract

Infectious virions of MP, a syncytial strain of herpes simplex virus type 1, are formed in the presence of 50 mM NH4Cl. Underglycosylated virion glycoproteins are synthesized in infected cells and are incorporated into virions in the presence of the same concentration of NH4Cl. We conclude that fully glycosylated glycoproteins are not required for viral infectivity. Virus particles, deficient in glycosylated glycoproteins, are assembled in the presence of tunicamycin but they are not infectious. The decrease in infectivity could be due to the decreased amount of the gB or possibly other peptides and/or to the lack of the high-mannose saccharides of precursor glycoproteins.

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Year:  1983        PMID： 6301148     DOI： 10.1016/0042-6822(83)90217-9

Source DB:  PubMed          Journal:  Virology        ISSN： 0042-6822            Impact factor:   3.616


  18 in total

1.  Glycoprotein K specified by herpes simplex virus type 1 is expressed on virions as a Golgi complex-dependent glycosylated species and functions in virion entry.

Authors:  T P Foster; G V Rybachuk; K G Kousoulas
Journal:  J Virol       Date:  2001-12       Impact factor: 5.103

2.  Packaging of the virion host shutoff (Vhs) protein of herpes simplex virus: two forms of the Vhs polypeptide are associated with intranuclear B and C capsids, but only one is associated with enveloped virions.

Authors:  G Sullivan Read; Mary Patterson
Journal:  J Virol       Date:  2006-11-08       Impact factor: 5.103

3.  The UL20 gene of herpes simplex virus 1 encodes a function necessary for viral egress.

Authors:  J D Baines; P L Ward; G Campadelli-Fiume; B Roizman
Journal:  J Virol       Date:  1991-12       Impact factor: 5.103

4.  Absence of asparagine-linked oligosaccharides from glycoprotein D of herpes simplex virus type 1 results in a structurally altered but biologically active protein.

Authors:  D L Sodora; G H Cohen; M I Muggeridge; R J Eisenberg
Journal:  J Virol       Date:  1991-08       Impact factor: 5.103

5.  Herpes simplex virus envelopment and maturation studied by fracture label.

Authors:  M R Torrisi; C Di Lazzaro; A Pavan; L Pereira; G Campadelli-Fiume
Journal:  J Virol       Date:  1992-01       Impact factor: 5.103

6.  Antigenic variation (mar mutations) in herpes simplex virus glycoprotein B can induce temperature-dependent alterations in gB processing and virus production.

Authors:  S D Marlin; S L Highlander; T C Holland; M Levine; J C Glorioso
Journal:  J Virol       Date:  1986-07       Impact factor: 5.103

7.  Epstein-Barr virus glycoprotein homologous to herpes simplex virus gB.

Authors:  M Gong; T Ooka; T Matsuo; E Kieff
Journal:  J Virol       Date:  1987-02       Impact factor: 5.103

8.  Characterization of herpes simplex virus-containing organelles by subcellular fractionation: role for organelle acidification in assembly of infectious particles.

Authors:  C A Harley; A Dasgupta; D W Wilson
Journal:  J Virol       Date:  2001-02       Impact factor: 5.103

9.  Herpes simplex virus type 1 glycoprotein K is not essential for infectious virus production in actively replicating cells but is required for efficient envelopment and translocation of infectious virions from the cytoplasm to the extracellular space.

Authors:  S Jayachandra; A Baghian; K G Kousoulas
Journal:  J Virol       Date:  1997-07       Impact factor: 5.103

10.  Effect of brefeldin A on alphaherpesvirus membrane protein glycosylation and virus egress.

Authors:  M E Whealy; J P Card; R P Meade; A K Robbins; L W Enquist
Journal:  J Virol       Date:  1991-03       Impact factor: 5.103
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