Literature DB >> 6299689

Biological activities and receptor interactions of des-Leu16 salmon and des-Phe16 human calcitonin.

D M Findlay, V P Michelangeli, R C Orlowski, T J Martin.   

Abstract

Analogs of salmon (des-Leu16 sCT) and human (des-Phe16 hCT) calcitonin were prepared in which the amino acid from position 16 was omitted. The biological activities were assessed in vivo in the rat hypocalcemic assay and in vitro by studying competition for binding of [125I]sCT and adenylate cyclase stimulation in human breast cancer cells (T 47D). Deletion from position 16 resulted in substantial loss of biological activity in each system, indicating the importance for a hydrophobic residue at position 16 in the intact calcitonin molecule.

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Year:  1983        PMID： 6299689     DOI： 10.1210/endo-112-4-1288

Source DB:  PubMed          Journal:  Endocrinology        ISSN： 0013-7227            Impact factor:   4.736


  8 in total

Review 1.  Membrane catalysis of peptide-receptor binding.

Authors:  David N Langelaan; Jan K Rainey
Journal:  Biochem Cell Biol       Date:  2010-04       Impact factor: 3.626

2.  Abundant calcitonin receptors in isolated rat osteoclasts. Biochemical and autoradiographic characterization.

Authors:  G C Nicholson; J M Moseley; P M Sexton; F A Mendelsohn; T J Martin
Journal:  J Clin Invest       Date:  1986-08       Impact factor: 14.808

Review 3.  Peptides from the calcitonin genes: molecular genetics, structure and function.

Authors:  L H Breimer; I MacIntyre; M Zaidi
Journal:  Biochem J       Date:  1988-10-15       Impact factor: 3.857

4.  Characterization of an osteoblast-like clonal cell line which responds to both parathyroid hormone and calcitonin.

Authors:  S M Forrest; K W Ng; D M Findlay; V P Michelangeli; S A Livesey; N C Partridge; J D Zajac; T J Martin
Journal:  Calcif Tissue Int       Date:  1985-01       Impact factor: 4.333

5.  Reversible calcitonin binding to solubilized sheep brain binding sites.

Authors:  P M Sexton; H G Schneider; C S D'Santos; F A Mendelsohn; B E Kemp; J M Moseley; T J Martin; D M Findlay
Journal:  Biochem J       Date:  1991-01-01       Impact factor: 3.857

Review 6.  Amylin structure-function relationships and receptor pharmacology: implications for amylin mimetic drug development.

Authors:  Rebekah L Bower; Debbie L Hay
Journal:  Br J Pharmacol       Date:  2016-05-18       Impact factor: 8.739

7.  Human placental calcitonin receptors.

Authors:  G C Nicholson; C S D'Santos; T Evans; J M Moseley; B E Kemp; V P Michelangeli; T J Martin
Journal:  Biochem J       Date:  1988-03-15       Impact factor: 3.857

8.  Monosialoganglioside-GM1 triggers binding of the amyloid-protein salmon calcitonin to a Langmuir membrane model mimicking the occurrence of lipid-rafts.

Authors:  Marco Diociaiuti; Cristiano Giordani; Gihan S Kamel; Francesco Brasili; Simona Sennato; Cecilia Bombelli; Karen Y Meneses; Marco A Giraldo; Federico Bordi
Journal:  Biochem Biophys Rep       Date:  2016-10-15
  8 in total

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