| Literature DB >> 6299513 |
I Parsa, A L Sutton, C K Chen, C Delbridge.
Abstract
Monoclonal antibody to duct cell surface marker (HP-DU-1), produced by hybridoma, was shown to be specific to duct cell surface antigen when tested against normal adult and 12-20-week-old fetal human pancreases. There were no common HLA antigens for locus A, B, C and DR among the 10 pancreas donors; nor did HP-DU-1 reveal any affinity for lymphocytes of donors whose pancreases were used as antigen for immunization of BALB/c mice. Seven out of 7 human pancreas adenocarcinomas including a poorly differentiated human pancreatic tumor expressed surface determinants detectable by HP-DU-1. Cell lines CAPAN-1 and CAPAN-2, derived from human pancreatic adenocarcinoma, also revealed the same antigenic determinants.Entities:
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Year: 1982 PMID： 6299513 DOI： 10.1016/0304-3835(82)90035-0
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679