Literature DB >> 6299236

Effect of acyclovir and presence of cellular and viral thymidine kinase activity in herpes simplex virus infected cells. Brief report.

J Harmenberg, C F Källander, J S Gronowitz.   

Abstract

Herpes simplex type 1 (HSV-1) infected human lung fibroblasts show a higher viral thymidine kinase activity than infected African green monkey kidney cells. This may partly account for the higher antiviral activity of acyclovir in the former cells.

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Year:  1982        PMID： 6299236     DOI： 10.1007/bf01314715

Source DB:  PubMed          Journal:  Arch Virol        ISSN： 0304-8608            Impact factor:   2.574


  11 in total

1.  Thymidine kinase from herpes simplex virus phosphorylates the new antiviral compound, 9-(2-hydroxyethoxymethyl)guanine.

Authors:  J A Fyfe; P M Keller; P A Furman; R L Miller; G B Elion
Journal:  J Biol Chem       Date:  1978-12-25       Impact factor: 5.157

2.  Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl) guanine.

Authors:  G B Elion; P A Furman; J A Fyfe; P de Miranda; L Beauchamp; H J Schaeffer
Journal:  Proc Natl Acad Sci U S A       Date:  1977-12       Impact factor: 11.205

3.  Properties of mitochondrial thymidine kinases of parental and enzyme-deficient HeLa cells.

Authors:  S Kit; W C Leung; D Trkula
Journal:  Arch Biochem Biophys       Date:  1973-10       Impact factor: 4.013

Review 4.  Viral-associated and induced enzymes.

Authors:  S Kit
Journal:  Pharmacol Ther B       Date:  1979

5.  Differential activity of potential antiviral nucleoside analogs on herpes simplex virus-induced and human cellular thymidine kinases.

Authors:  Y C Cheng; G Dutschman; J J Fox; K A Watanabe; H Machida
Journal:  Antimicrob Agents Chemother       Date:  1981-09       Impact factor: 5.191

6.  Rapid typing of herpes simplex virus based on immunological specificity of viral thymidine kinase and typing according to sensitivity to iododeoxyuridine.

Authors:  J S Gronowitz; C F Källander; S Jeansson; J Wallin
Journal:  J Clin Microbiol       Date:  1982-03       Impact factor: 5.948

7.  Influence of cell culture conditions on the inhibition of herpes simplex virus type 1 replication by acyclovir.

Authors:  J Harmenberg; B Wahren
Journal:  Intervirology       Date:  1982       Impact factor: 1.763

8.  Metabolism of acyclovir in virus-infected and uninfected cells.

Authors:  P A Furman; P de Miranda; M H St Clair; G B Elion
Journal:  Antimicrob Agents Chemother       Date:  1981-10       Impact factor: 5.191

9.  Optimized assay for thymidine kinase and its application to the detection of antibodies against herpes simplex virus type 1- and 2-induced thymidine kinase.

Authors:  J S Gronowitz; C F Källander
Journal:  Infect Immun       Date:  1980-08       Impact factor: 3.441

10.  Influence of cells and virus multiplicity on the inhibition of herpesviruses with acycloguanosine.

Authors:  J Harmenberg; B Wahren; B Oberg
Journal:  Intervirology       Date:  1980       Impact factor: 1.763
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  3 in total

1.  Influence of acyclovir and bucyclovir on nucleotide pools in cells infected with herpes simplex virus type 1.

Authors:  A H Karlsson; J G Harmenberg; B E Wahren
Journal:  Antimicrob Agents Chemother       Date:  1986-05       Impact factor: 5.191

2.  Efficacies of antiherpesvirus nucleosides against two strains of herpes simplex virus type 1 in Vero and human embryo lung fibroblast cells.

Authors:  T Suzutani; H Machida; T Sakuma
Journal:  Antimicrob Agents Chemother       Date:  1988-07       Impact factor: 5.191

3.  Antiviral activities of guanosine analogs in guinea pig embryonic fibroblasts.

Authors:  J Harmenberg; K Stenberg
Journal:  Antimicrob Agents Chemother       Date:  1988-10       Impact factor: 5.191
  3 in total

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