| Literature DB >> 6298893 |
J C Schwartz, S De La Baume, C C Yi, P Chaillet, H Marcais-Collado, J Costentin.
Abstract
Various cerebral peptidases are able to hydrolyse the enkephalins into inactive fragments. Among these enzymes enkephalin-dipeptidylcarboxypeptidase ("enkephalinase") inhibited by thiorphan and a bestatin-sensitive aminopeptidase activity seem to play a key-role as "inactivating neuropeptidases". Their inhibition, in vitro as well as in vivo, leads to a protection of endogenous enkephalins and to antinociceptive effects.Entities:
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Year: 1982 PMID： 6298893 DOI： 10.1016/s0278-5846(82)80166-8
Source DB: PubMed Journal: Prog Neuropsychopharmacol Biol Psychiatry ISSN： 0278-5846 Impact factor: 5.067