Literature DB >> 629879

Leg ulcers in alpha-thalassaemia (haemoglobin H disease).

T K Daneshmend, R D Peachey.   

Abstract

A case of recurrent leg ulceration associated with alpha-thalassaemia (haemoglobin H disease) is reported. It is suggested that leg ulcers occurring in the thalassaemic syndromes may be due to structural changes in the affected red cells which result in increased cell rigidity, decreased deformability and consequent diminished blood flow in capillary beds that are subjected to venous stasis.

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Year:  1978        PMID： 629879     DOI： 10.1111/j.1365-2133.1978.tb01629.x

Source DB:  PubMed          Journal:  Br J Dermatol        ISSN： 0007-0963            Impact factor:   9.302


  3 in total

1.  Sickle cell leg ulcers: associations with haemolysis and SNPs in Klotho, TEK and genes of the TGF-beta/BMP pathway.

Authors:  Vikki G Nolan; Adeboye Adewoye; Clinton Baldwin; Ling Wang; Qianli Ma; Diego F Wyszynski; John J Farrell; Paola Sebastiani; Lindsay A Farrer; Martin H Steinberg
Journal:  Br J Haematol       Date:  2006-06       Impact factor: 6.998

2.  Ocular findings in a case of haemoglobin H disease.

Authors:  T K Daneshmend
Journal:  Br J Ophthalmol       Date:  1979-12       Impact factor: 4.638

Review 3.  Leg Ulcers: A Report in Patients with Hemoglobin E Beta Thalassemia and Review of the Literature in Severe Beta Thalassemia.

Authors:  Vikita Mehta; Abirami Kirubarajan; Amir Sabouhanian; Sanasi M Jayawardena; Priya Chandrakumaran; Nila Thangavelu; Refai Cader; Sachith Mettananda; Dayananda Bandara; Shawn Khan; David J Weatherall; Angela Allen; Anuja P Premawardhena; Nancy F Olivieri
Journal:  Acta Haematol       Date:  2021-11-09       Impact factor: 3.068
  3 in total

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