| Literature DB >> 6298666 |
Abstract
A low concentration of high-affinity, saturable and specific [3H]GABA binding sites has been identified in a membrane fraction of rat oviduct. The specific binding of [3H]GABA was displaced by unlabelled GABA, muscimol and bicuculline. Furthermore in oviductal slices, GABA and a known GABA receptor agonist, i.e. muscimol, produced a significant elevation of cyclic AMP levels, which could be antagonized by GABA receptor blockers, i.e. picrotoxin and bicuculline. The present results indicate that GABA receptors may have a functional significance in rat oviduct.Entities:
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Year: 1982 PMID： 6298666 DOI： 10.1016/0304-3940(82)90384-6
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046