Genetic variation in testicular LH receptors in the mouse.

The concentration of testicular hCG (LH) binding sites was measured in five mutants with defective endocrine and/or reproductive functions, in a hypoandrogenic inbred strain and in six normal strains. A decrease in hCG binding was found in dw/dw mice, and an increase in Tfm/y and C57Bl10/J mice. Analysis of the results indicates the existence of a genetic factor(s) involved in the regulation of hCG (LH) binding.