Literature DB >> 6297

Is glutamic acid the pyramidal tract neurotransmitter?

T W Stone.   

Abstract

Applied by microiontophoresis, 1-hydroxy-3-amino-pyrrolidone-2 (HA-966) antagonized excitation by glutamic acid but not by acetylcholine of neurones in the rat cuneate nucleus. HA-966 blocked the short latency excitation of cuneate neurones following stimulation of the pyramidal tract on 28 of 40 cells (70%). Thus, glutamate or a related amino-acid may be the neurotransmitter released by pyramidal tract neurones.

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Year:  1976        PMID： 6297     DOI： 10.1007/BF01990174

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  20 in total

1.  Cellular localization of brain monoamines.

Authors:  A CARLSSON; B FALCK; N A HILLARP
Journal:  Acta Physiol Scand Suppl       Date:  1962

2.  Corticofugal fibres to the nuclei of the dorsal columns; an experimental study in the cat.

Authors:  F WALBERG
Journal:  Brain       Date:  1957-06       Impact factor: 13.501

3.  The histochemical localization of cholinesterases in the central nervous system of the rat.

Authors:  G B KOELLE
Journal:  J Comp Neurol       Date:  1954-02       Impact factor: 3.215

4.  Acetylcholine synthesis in different regions of the central nervous system.

Authors:  W Feldberg; M Vogt
Journal:  J Physiol       Date:  1948-06-25       Impact factor: 5.182

5.  Microelectrophoretic studies on the depressant action of HA-966 on chemically and synaptically excited neurones in the cat cerebral cortex and cuneate nucleus.

Authors:  J Davies; J C Watkins
Journal:  Brain Res       Date:  1973-09-14       Impact factor: 3.252

6.  Antagonism of synaptic and amino acid induced excitation in the cuneate nucleus of the cat by HA-966.

Authors:  J Davies; J C Watkins
Journal:  Neuropharmacology       Date:  1973-07       Impact factor: 5.250

7.  Metabolism of glucose and glutamate by synaptosomes from mammalian cerebral cortex.

Authors:  H F Bradford; A J Thomas
Journal:  J Neurochem       Date:  1969-11       Impact factor: 5.372

8.  Actions of L-glutamate, acetylcholine and dopamine on single neurons in the nuclei cuneatus and gracilis of the cat.

Authors:  F A Steiner; M Meyer
Journal:  Experientia       Date:  1966-01-15

9.  Micro-iontophoretic studies on neurones in the cuneate nucleus.

Authors:  A Galindo; K Krnjević; S Schwartz
Journal:  J Physiol       Date:  1967-09       Impact factor: 5.182

10.  Cholinergic mechanisms in the rat somatosensory cerebral cortex.

Authors:  T W Stone
Journal:  J Physiol       Date:  1972-09       Impact factor: 5.182
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  2 in total

1.  Distribution and uptake of glycine, glutamate and gamma-aminobutyric acid in the vagal nuclei and eight other regions of the rat medulla oblongata.

Authors:  E R Siemers; M A Rea; D L Felten; M H Aprison
Journal:  Neurochem Res       Date:  1982-04       Impact factor: 3.996

Review 2.  Pyroglutamic acid. Non-metabolic formation, function in proteins and peptides, and characteristics of the enzymes effecting its removal.

Authors:  G N Abraham; D N Podell
Journal:  Mol Cell Biochem       Date:  1981-08-11       Impact factor: 3.396
  2 in total

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