Literature DB >> 6296861

Ascorbate-quinone interactions: electrochemical, free radical, and cytotoxic properties.

R Pethig, P R Gascoyne, J A McLaughlin, A Szent-Györgyi.   

Abstract

Standard midpoint potentials have been determined for p-benzoquinone, methoxy-p-benzoquinone and 2,3-, 2,5-, and 2,6-dimethoxy-p-benzoquinones in aqueous solution. ESR studies have been made of the ascorbate and semiquinone radicals produced when these quinones interact with sodium ascorbate. Direct correlations are found between the electrochemical potentials, generated semiquinone lifetimes, and cytotoxic action in Ehrlich ascites-bearing mice.

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Year:  1983        PMID： 6296861      PMCID： PMC393323          DOI： 10.1073/pnas.80.1.129

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  4 in total

1.  ELECTRON PARAMAGNETIC RESONANCE OF UNDISSOCIATED P-BENZOSEMIQUINONES.

Authors:  I YAMAZAKI; L H PIETTE
Journal:  J Am Chem Soc       Date:  1965-03-05       Impact factor: 15.419

2.  Electronic properties of the casein-methylglyoxal complex.

Authors:  R Pethig; A Szent-Györgyi
Journal:  Proc Natl Acad Sci U S A       Date:  1977-01       Impact factor: 11.205

3.  A general mechanism for microsomal activation of quinone anticancer agents to free radicals.

Authors:  N R Bachur; S L Gordon; M V Gee
Journal:  Cancer Res       Date:  1978-06       Impact factor: 12.701

4.  Water structure-dependent charge transport in proteins.

Authors:  P R Gascoyne; R Pethig; A Szent-Györgyi
Journal:  Proc Natl Acad Sci U S A       Date:  1981-01       Impact factor: 11.205
  4 in total
  12 in total

1.  Natural low-molecular mass organic compounds with oxidase activity as organocatalysts.

Authors:  Tatsuya Nishiyama; Yoshiteru Hashimoto; Hitoshi Kusakabe; Takuto Kumano; Michihiko Kobayashi
Journal:  Proc Natl Acad Sci U S A       Date:  2014-11-19       Impact factor: 11.205

2.  Mechanism of Intrinsic Chemiluminescence Production from the Degradation of Persistent Chlorinated Phenols by the Fenton System: A Structure-Activity Relationship Study and the Critical Role of Quinoid and Semiquinone Radical Intermediates.

Authors:  Hui-Ying Gao; Li Mao; Feng Li; Lin-Na Xie; Chun-Hua Huang; Jie Shao; Bo Shao; Balaraman Kalyanaraman; Ben-Zhan Zhu
Journal:  Environ Sci Technol       Date:  2017-02-17       Impact factor: 9.028

3.  Interactions between ascorbyl free radical and coenzyme Q at the plasma membrane.

Authors:  A Arroyo; F Navarro; C Gómez-Díaz; F L Crane; F J Alcaín; P Navas; J M Villalba
Journal:  J Bioenerg Biomembr       Date:  2000-04       Impact factor: 2.945

Review 4.  Evolution of cytochrome bc complexes: from membrane-anchored dehydrogenases of ancient bacteria to triggers of apoptosis in vertebrates.

Authors:  Daria V Dibrova; Dmitry A Cherepanov; Michael Y Galperin; Vladimir P Skulachev; Armen Y Mulkidjanian
Journal:  Biochim Biophys Acta       Date:  2013-07-19

5.  Interaction of the 2,6-dimethoxysemiquinone and ascorbyl free radicals with Ehrlich ascites cells: a probe of cell-surface charge.

Authors:  R Pethig; P R Gascoyne; J A McLaughlin; A Szent-Györgyi
Journal:  Proc Natl Acad Sci U S A       Date:  1984-04       Impact factor: 11.205

6.  Enzyme-controlled scavenging of ascorbyl and 2,6-dimethoxy-semiquinone free radicals in Ehrlich ascites tumor cells.

Authors:  R Pethig; P R Gascoyne; J A McLaughlin; A Szent-Györgyi
Journal:  Proc Natl Acad Sci U S A       Date:  1985-03       Impact factor: 11.205

7.  Differential stress-induced regulation of two quinone reductases in the brown rot basidiomycete Gloeophyllum trabeum.

Authors:  Roni Cohen; Melissa R Suzuki; Kenneth E Hammel
Journal:  Appl Environ Microbiol       Date:  2004-01       Impact factor: 4.792

8.  Effect of tingenone, a quinonoid triterpene, on growth and macromolecule biosynthesis in Trypanosoma cruzi.

Authors:  S G Goijman; J F Turrens; G B Marini-Bettolo; A O Stoppani
Journal:  Experientia       Date:  1985-05-15

9.  Antiproliferative and antimetabolic effects behind the anticancer property of fermented wheat germ extract.

Authors:  Christoph Otto; Theresa Hahlbrock; Kilian Eich; Ferdi Karaaslan; Constantin Jürgens; Christoph-Thomas Germer; Armin Wiegering; Ulrike Kämmerer
Journal:  BMC Complement Altern Med       Date:  2016-06-01       Impact factor: 3.659

10.  Impact of Antioxidants on Cardiolipin Oxidation in Liposomes: Why Mitochondrial Cardiolipin Serves as an Apoptotic Signal?

Authors:  Alexey V Lokhmatikov; Natalia Voskoboynikova; Dmitry A Cherepanov; Maxim V Skulachev; Heinz-Jürgen Steinhoff; Vladimir P Skulachev; Armen Y Mulkidjanian
Journal:  Oxid Med Cell Longev       Date:  2016-05-26       Impact factor: 6.543
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