Literature DB >> 6296837

Isolated poliovirus capsid protein VP1 induces a neutralizing response in rats.

M Chow, D Baltimore.   

Abstract

Antibodies were raised in rats against the poliovirus type 1 capsid proteins, VP1, VP2, and VP3. Antibodies directed against VP1 from type 1 poliovirus (Mahoney) neutralized type 1 but not type 2 poliovirus. Antibodies raised against VP2 and VP3 failed to neutralize type 1 virus. Thus, VP1 appears to be a neutralizing antigen for poliovirus and in its denatured form presents to the immune system its neutralizing determinants.

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Year:  1982        PMID： 6296837      PMCID： PMC347371          DOI： 10.1073/pnas.79.23.7518

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  22 in total

1.  Immunochemical studies of poliovirus. III. Further studies on the immunologic and physical properties of poliovirus particles produced in tissue culture.

Authors:  B ROIZMAN; M M MAYER; H J RAPP
Journal:  J Immunol       Date:  1958-11       Impact factor: 5.422

2.  Studies on the complement fixing antigens of poliomyelitis. I. Demonstration of type and group specific antigens in native and heated viral preparations.

Authors:  K HUMMELER; V V HAMPARIAN
Journal:  J Immunol       Date:  1958-12       Impact factor: 5.422

3.  Identification of poliovirus particles of different antigenicity by specific agglutination as seen in the electron microscope.

Authors:  K HUMMELER; T F ANDERSON; R A BROWN
Journal:  Virology       Date:  1962-01       Impact factor: 3.616

4.  The D to C change in poliovirus particles.

Authors:  G L LE BOUVIER
Journal:  Br J Exp Pathol       Date:  1959-12

5.  Studies on the complement-fixing antigens of poliomylitis. II. Preparation of type-specific anti-N and anti-H indicator sera.

Authors:  K HUMMELER; J J TUMILOWICZ
Journal:  J Immunol       Date:  1960-06       Impact factor: 5.422

6.  Structure of the Mengo virion. V. Distribution of the capsid polypeptides with respect to the surface of the virus particle.

Authors:  G A Lund; B R Ziola; A Salmi; D G Scraba
Journal:  Virology       Date:  1977-05-01       Impact factor: 3.616

7.  VP 4, the D-reactive part of poliovirus.

Authors:  M Breindl
Journal:  Virology       Date:  1971-12       Impact factor: 3.616

8.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

9.  A neutralizing monoclonal antibody against poliovirus and its reaction with related antigens.

Authors:  J Icenogle; S F Gilbert; J Grieves; J Anderegg; R Rueckert
Journal:  Virology       Date:  1981-11       Impact factor: 3.616

10.  Topographical studies on poliovirus capsid proteins by chemical modification and cross-linking with bifunctional reagents.

Authors:  K Wetz; K O Habermehl
Journal:  J Gen Virol       Date:  1979-08       Impact factor: 3.891
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  25 in total

1.  Myristate-protein interactions in poliovirus: interactions of VP4 threonine 28 contribute to the structural conformation of assembly intermediates and the stability of assembled virions.

Authors:  N Moscufo; M Chow
Journal:  J Virol       Date:  1992-12       Impact factor: 5.103

2.  Effects of hydrostatic pressure on a membrane-enveloped virus: high immunogenicity of the pressure-inactivated virus.

Authors:  J L Silva; P Luan; M Glaser; E W Voss; G Weber
Journal:  J Virol       Date:  1992-04       Impact factor: 5.103

3.  Biosynthesis, maturation, and acid activation of the Semliki Forest virus fusion protein.

Authors:  M Kielian; S Jungerwirth; K U Sayad; S DeCandido
Journal:  J Virol       Date:  1990-10       Impact factor: 5.103

4.  Molecular basis for linkage of a continuous and discontinuous neutralization epitope on the structural polypeptide VP2 of poliovirus type 1.

Authors:  K J Wiegers; K Wetz; R Dernick
Journal:  J Virol       Date:  1990-03       Impact factor: 5.103

5.  Myristoylation is important at multiple stages in poliovirus assembly.

Authors:  N Moscufo; J Simons; M Chow
Journal:  J Virol       Date:  1991-05       Impact factor: 5.103

6.  Mutations conferring resistance to neutralization with monoclonal antibodies in type 1 poliovirus can be located outside or inside the antibody-binding site.

Authors:  B Blondel; R Crainic; O Fichot; G Dufraisse; A Candrea; D Diamond; M Girard; F Horaud
Journal:  J Virol       Date:  1986-01       Impact factor: 5.103

7.  Regions of poliovirus protein VP1 produced in Escherichia coli induce neutralizing antibodies.

Authors:  M E Hoatlin; O M Kew; M E Renz
Journal:  J Virol       Date:  1987-05       Impact factor: 5.103

8.  Synthetic peptides from four separate regions of the poliovirus type 1 capsid protein VP1 induce neutralizing antibodies.

Authors:  M Chow; R Yabrov; J Bittle; J Hogle; D Baltimore
Journal:  Proc Natl Acad Sci U S A       Date:  1985-02       Impact factor: 11.205

9.  Poliovirus-specific major histocompatibility complex class I-restricted cytolytic T-cell epitopes in mice localize to neutralizing antigenic regions.

Authors:  M Kutubuddin; J Simons; M Chow
Journal:  J Virol       Date:  1992-10       Impact factor: 5.103

10.  Cholesterol removal by methyl-beta-cyclodextrin inhibits poliovirus entry.

Authors:  Pranav Danthi; Marie Chow
Journal:  J Virol       Date:  2004-01       Impact factor: 5.103
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