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Literature DB >> 6295855

Restriction fragment length polymorphism of the insulin gene in diabetes mellitus.

Abstract

Variant DNA sequences flanking the human insulin gene were found in the Danish population using restriction endonucleases (restriction fragment length polymorphism). The frequencies of these DNA sequences were determined in 47 non-insulin-dependent diabetics and 93 control individuals. We report an association between a restriction fragment length polymorphism of the insulin gene and NIDDM.

Entities: Disease Gene Species

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Year: 1982 PMID： 6295855 DOI： 10.2337/diab.31.3.275

Source DB: PubMed Journal: Diabetes ISSN： 0012-1797 Impact factor: 9.461

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Cited

42 in total

Review 1. Candidate genes for type 2 diabetes.

Authors: Hemang Parikh; Leif Groop
Journal: Rev Endocr Metab Disord Date: 2004-05 Impact factor: 6.514

2. In Finland insulin gene region encoded susceptibility to IDDM exerts maximum effect when there is low HLA-DR associated risk. DiMe (Childhood Diabetes in Finland) Study Group.

Authors: K A Metcalfe; G A Hitman; M J Fennessy; M I McCarthy; J Tuomilehto; E Tuomilehto-Wolf
Journal: Diabetologia Date: 1995-10 Impact factor: 10.122

3. Multipoint linkage analysis of the short arm of chromosome 11 in non-insulin dependent diabetes including maturity onset diabetes of youth.

Authors: S O'Rahilly; P Patel; O J Lehmann; A Tybjaerg-Hansen; J Nerup; R C Turner; J S Wainscoat
Journal: Hum Genet Date: 1992-05 Impact factor: 4.132

9. The genotypic distribution among non-insulin-dependent diabetes mellitus (NIDDM) patients of a restriction fragment length polymorphism.

Authors: G Thomson
Journal: Am J Hum Genet Date: 1984-03 Impact factor: 11.025

10. The aggregation of the 5' insulin gene polymorphism in insulin dependent (type I) diabetes mellitus families.

Authors: L J Raffel; G A Hitman; H Toyoda; J H Karam; G I Bell; J I Rotter
Journal: J Med Genet Date: 1992-07 Impact factor: 6.318

Restriction fragment length polymorphism of the insulin gene in diabetes mellitus.

Review 1. Candidate genes for type 2 diabetes.

2. In Finland insulin gene region encoded susceptibility to IDDM exerts maximum effect when there is low HLA-DR associated risk. DiMe (Childhood Diabetes in Finland) Study Group.

3. Multipoint linkage analysis of the short arm of chromosome 11 in non-insulin dependent diabetes including maturity onset diabetes of youth.

4. A genome-inspired DNA ligand for the affinity capture of insulin and insulin-like growth factor-2.

5. Gene probes to detect cross-culture contamination in hormone producing cell lines.

6. Allelic variation adjacent to the human insulin and apolipoprotein C-II genes in different ethnic groups.

7. Evidence for increased recombination near the human insulin gene: implication for disease association studies.

8. Newborn screening for HLA markers associated with IDDM: diabetes autoimmunity study in the young (DAISY).

9. The genotypic distribution among non-insulin-dependent diabetes mellitus (NIDDM) patients of a restriction fragment length polymorphism.

10. The aggregation of the 5' insulin gene polymorphism in insulin dependent (type I) diabetes mellitus families.