Literature DB >> 6295823

5-hydroxytryptamine and precapillary vessels.

J M Van Nueten.   

Abstract

The complexity of the vascular effects of 5-hydroxytryptamine (5-HT) is illustrated by differences in sensitivity to the amine among arterial tissues of different origin. The interaction of 5-HT with 5-HT2 receptors is inhibited by specific antagonists such as ketanserin and methysergide. Such compounds also inhibit the contractile responses to endogenous 5-HT released from aggregating platelets. The vasodilator component of the response to 5-HT can be unmasked in the presence of serotonergic blockade, provided the antagonist used has no partial agonistic properties. 5-HT augments (amplifies) the vasoconstrictor responses to adrenergic and nonadrenergic neurohumoral mediators. The amplifying effect of the monoamine is prevented by 5-HT2-serotonergic antagonists such as ketanserin.

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Year:  1983        PMID： 6295823

Source DB:  PubMed          Journal:  Fed Proc        ISSN： 0014-9446


  9 in total

1.  Comparison of the effects of cromakalim, a potassium conductance enhancer, and nimodipine, a calcium antagonist, on 5-hydroxytryptamine responses in a variety of vascular smooth muscle preparations.

Authors:  C R Cain; C D Nicholson
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1989-09       Impact factor: 3.000

2.  The state of the renin-angiotensin-aldosterone system in patients with the neuroendocrine-metabolic form of the hypothalamic syndrome.

Authors:  V N Slavnov; V V Markov; V M Rudichenko; E V Luchitskii; V A Oleinik
Journal:  Neurosci Behav Physiol       Date:  1993 May-Jun

Review 3.  Cardiovascular responses produced by 5-hydroxytriptamine:a pharmacological update on the receptors/mechanisms involved and therapeutic implications.

Authors:  Carlos M Villalón; David Centurión
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2007-08-17       Impact factor: 3.000

4.  Mechanisms of the ergonovine-induced vasoconstriction in the rabbit main coronary artery.

Authors:  A Suyama; H Kuriyama
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1984-07       Impact factor: 3.000

5.  Serotonin (5-HT) and the rat's eye. Some pilot studies.

Authors:  R M Boerrigter; J V Siertsema; I P Kema
Journal:  Doc Ophthalmol       Date:  1992       Impact factor: 2.379

6.  The direct and amplifying effects of serotonin are increased with age in the isolated perfused kidney of Wistar and spontaneously hypertensive rats.

Authors:  W J Janssens; J M Van Nueten
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1986-12       Impact factor: 3.000

7.  The sensitivity of human blood platelets to the aggregating agent ADP during different dietary sodium intakes in healthy men.

Authors:  I F Gow; M Dockrell; C R Edwards; A Elder; J Grieve; G Kane; P L Padfield; C J Waugh; B C Williams
Journal:  Eur J Clin Pharmacol       Date:  1992       Impact factor: 2.953

Review 8.  Platelet-vessel wall interactions: implication of 5-hydroxytryptamine. A review.

Authors:  F De Clerck; J M van Nueten; R S Reneman
Journal:  Agents Actions       Date:  1984-12

9.  Enhancement by serotonin of intra-tumour penetration of spleen cells.

Authors:  G Lespinats; M Bonnet; S Tlouzeau; C Burtin
Journal:  Br J Cancer       Date:  1984-10       Impact factor: 7.640
  9 in total

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