Literature DB >> 6295783

Possible presynaptic inhibitory effect of etorphine on sympathetic nerve terminals of guinea-pig heart.

F Ledda, L Mantelli.   

Abstract

Etorphine (1-4 microM) dose dependently reduced the sympathetic response induced by trains of field pulses in guinea-pig isolated atria stimulated at 4 Hz; this effect was antagonized by 10 microM naloxone. Since etorphine did not modify the dose-inotropic effect curve of exogenous noradrenaline in the same preparation, it is suggested that the depressant effect of the opioid agonist was due to stimulation of presynaptic inhibitory opiate receptors on adrenergic nerve terminals of the heart.

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Year:  1982        PMID： 6295783     DOI： 10.1016/0014-2999(82)90476-9

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  7 in total

1.  Role of adrenoceptors in the potentiation of opioid antinociception by ephedrine and phenylpropanolamine in mice.

Authors:  Y M Dambisya; K Chan; C L Wong
Journal:  Psychopharmacology (Berl)       Date:  1991       Impact factor: 4.530

2.  The sympathetic axons innervating the sinus node of the rabbit possess presynaptic opioid kappa- but not mu- or delta-receptors.

Authors:  K Starke; E Schöffel; P Illes
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1985-04       Impact factor: 3.000

3.  Opioid peptides decrease noradrenaline release and blood pressure in the rabbit at peripheral receptors.

Authors:  B Szabo; L Hedler; H Ensinger; K Starke
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1986-01       Impact factor: 3.000

4.  Influence of the optical isomers (+)- and (-)-naloxone on beating frequency, contractile force and action potentials of guinea-pig isolated cardiac preparations.

Authors:  H Brasch
Journal:  Br J Pharmacol       Date:  1986-08       Impact factor: 8.739

5.  Ethylketocyclazocine decreases noradrenaline release and blood pressure in the rabbit at a peripheral opioid receptor.

Authors:  H Ensinger; L Hedler; C Schurr; K Starke
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1984-11       Impact factor: 3.000

6.  On the opioid receptor subtype inhibiting the evoked release of 3H-noradrenaline from guinea-pig atria in vitro.

Authors:  H Fuder; M Buder; H D Riers; G Rothacher
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1986-02       Impact factor: 3.000

Review 7.  Prospects for Creation of Cardioprotective and Antiarrhythmic Drugs Based on Opioid Receptor Agonists.

Authors:  Leonid N Maslov; Igor Khaliulin; Peter R Oeltgen; Natalia V Naryzhnaya; Jian-Ming Pei; Stephen A Brown; Yury B Lishmanov; James M Downey
Journal:  Med Res Rev       Date:  2016-05-16       Impact factor: 12.944
  7 in total

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