| Literature DB >> 6294827 |
Abstract
Epidermal growth factor, a potent mitogen, stimulates phosphorylation of its 170,000-dalton plasma membrane receptor. Dimethyl sulfoxide selectively increased phosphorylation of the epidermal growth factor receptor in rat liver microsomal fraction. Maximal stimulation occurred at 15 to 25 percent dimethyl sulfoxide and resembled the effect of epidermal growth factor in magnitude and rapidity. Like epidermal growth factor, dimethyl sulfoxide selectively stimulated tyrosine residue phosphorylation of this protein.Entities:
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Year: 1983 PMID: 6294827 DOI: 10.1126/science.6294827
Source DB: PubMed Journal: Science ISSN: 0036-8075 Impact factor: 47.728