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Literature DB >> 6294815

Inflammatory responses to intradermal crystals in healthy volunteers and patients with rheumatic diseases.

P A Dieppe, M Doherty, G M Papadimitriou.

Abstract

The inflammatory response to intradermal injections of urate, pyrophosphate and hydroxyapatite crystals in human forearm skin is described. Patients with rheumatoid arthritis responded normally to urate crystals, and patients with osteoarthritis or pyrophosphate arthropathy responded normally to hydroxyapatite and pyrophosphate crystals respectively. These results suggest that variation in host response to crystals cannot explain the different patterns of crystal-induced disease seen in man. The model, however, is recommended as a safe, simple ethical and reproducible test of inflammation in human subjects.

Entities: Chemical Disease Species

Mesh：

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Year: 1982 PMID： 6294815 DOI： 10.1007/bf00541246

Source DB: PubMed Journal: Rheumatol Int ISSN： 0172-8172 Impact factor: 2.631

11 in total

1. THE INFLAMMATORY RESPONSE TO INJECTED MICROCRYSTALLINE MONOSODIUM URATE IN NORMAL, HYPERURICEMIC, GOUTY, AND UREMIC SUBJECTS.

Authors: W W BUCHANAN; J R KLINENBERG; J E SEEGMILLER
Journal: Arthritis Rheum Date: 1965-06

2. Clearance of calcium pyrophosphate dihydrate crystals in vivo. I. Studies using 169Yb labeled triclinic crystals.

Authors: D J McCarty; D W Palmer; P B Halverson
Journal: Arthritis Rheum Date: 1979-07

Review 3. Calcium pyrophosphate dihydrate crystal deposition disease--1975.

Authors: D J McCarty
Journal: Arthritis Rheum Date: 1976 May-Jun

4. Definitive diagnosis of gout by identification of urate crystals in asymptomatic metatarsophalangeal joints.

Authors: C A Agudelo; A Weinberger; H R Schumacher; R Turner; J Molina
Journal: Arthritis Rheum Date: 1979-05

5. An experimental model of acute inflammation in man.

Authors: A D Steele; D J McCarty
Journal: Arthritis Rheum Date: 1966-06

6. Coexistent gout and rheumatoid arthritis. Case report and literature review.

Authors: D J Wallace; J R Klinenberg; D Morham; B Berlanstein; P C Biren; G Callis
Journal: Arthritis Rheum Date: 1979-01

7. Acute pseudogout: "crystal shedding" or acute crystallization?

Authors: M Doherty; P A Dieppe
Journal: Arthritis Rheum Date: 1981-07

8. The treatment of gout with azapropazone: clinical and experimental studies.

Authors: P A Dieppe; M Doherty; J T Whicher; G Walters
Journal: Eur J Rheumatol Inflamm Date: 1981

9. Structural changes in sodium urate crystals on heating.

Authors: N S Mandel
Journal: Arthritis Rheum Date: 1980-06

10. The effects of NSAID on monosodium-urate (MSU) skin test and on other in vivo skin tests (SK/SD; PHA).

Authors: U Ambanelli; G F Ferraccioli; P Manganelli; G L Vaona
Journal: Agents Actions Suppl Date: 1980

6 in total

1. Proceedings of a symposium on crystal-related arthropathies. 22 October and 23 October, 1982, Bristol Polytechnic, Bristol.

Authors:
Journal: Ann Rheum Dis Date: 1983-08 Impact factor: 19.103

5. Systemic response to local urate crystal induced inflammation in man: a possible model to study the acute phase response.

Authors: C W Hutton; A J Collins; R E Chambers; J Whicher; P A Dieppe
Journal: Ann Rheum Dis Date: 1985-08 Impact factor: 19.103

Review 6. Interactions between leukocytes and endothelial cells in gout: lessons from a self-limiting inflammatory response.

Authors: Dorian O Haskard; R Clive Landis
Journal: Arthritis Res Date: 2002-05-09