| Literature DB >> 6294699 |
X Pi-Sunyer, H R Kissileff, J Thornton, G P Smith.
Abstract
Six of eight obese men ate significantly less food during an intravenous infusion of the C-terminal octapeptide of cholecystokinin (CCK-8, 4 ng . kg-1 . min-1) than during a saline infusion in a double blind experimental paradigm. Subjects stopped eating sooner during CCK-8. CCK-8 did not change the rate of eating. No overt side effects were reported or observed. This is the first report of the satiety effect of CCK-8 in obese humans and it suggests that the therapeutic potential of CCK-8 for the treatment of obesity deserves investigation.Entities:
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Year: 1982 PMID： 6294699 DOI： 10.1016/0031-9384(82)90230-x
Source DB: PubMed Journal: Physiol Behav ISSN： 0031-9384