Literature DB >> 6293844

Protection against chemically induced seizures by 2-amino-7-phosphonoheptanoic acid.

S J Czuczwar, B Meldrum.   

Abstract

The anticonvulsant activity of 2-amino-7-phosphonoheptanoic acid (2APH) (an antagonist of excitation induced by N-methyl-D-aspartic acid) was studied against N-methyl-DL-aspartic acid (NMDLA), kainic acid, 3-mercaptopropionic acid (3MPA), thiosemicarbazide (TSC), quinolinic acid, bicuculline, picrotoxin and methyl-6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate (DMCM) in Swiss S mice. 2APH, 0.33 mM/kg i.p., antagonizes convulsions induced by NMDLA, 3MPA, TSC, DMCM and picrotoxin but not those produced by the other convulsants. It is proposed that an aspartergic component may contribute to the development of convulsions after 3MPA, TSC, DMCM and picrotoxin.

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Year:  1982        PMID： 6293844     DOI： 10.1016/0014-2999(82)90273-4

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  19 in total

1.  Comparative analysis of seizures induced by intracerebroventricular administration of NMDA, kainate and quisqualate in mice.

Authors:  C Mathis; A Ungerer
Journal:  Exp Brain Res       Date:  1992       Impact factor: 1.972

2.  Behavioral characterization of GLT1 (+/-) mice as a model of mild glutamatergic hyperfunction.

Authors:  Anna Kiryk; Tomomi Aida; Kohichi Tanaka; Pradeep Banerjee; Grzegorz M Wilczynski; Ksenia Meyza; Ewelina Knapska; Robert K Filipkowski; Leszek Kaczmarek; Wojciech Danysz
Journal:  Neurotox Res       Date:  2008-01       Impact factor: 3.911

Review 3.  A review of the in vitro and in vivo neurochemical characterization of the NMDA/PCP/glycine/ion channel receptor macrocomplex.

Authors:  P L Wood; T S Rao; S Iyengar; T Lanthorn; J Monahan; A Cordi; E Sun; M Vazquez; N Gray; P Contreras
Journal:  Neurochem Res       Date:  1990-02       Impact factor: 3.996

4.  Convulsions induced by centrally administered NMDA in mice: effects of NMDA antagonists, benzodiazepines, minor tranquilizers and anticonvulsants.

Authors:  J L Moreau; L Pieri; B Prud'hon
Journal:  Br J Pharmacol       Date:  1989-11       Impact factor: 8.739

5.  Interactions of excitatory amino acid antagonists with conventional antiepileptic drugs.

Authors:  S J Czuczwar; W A Turski; Z Kleinrok
Journal:  Metab Brain Dis       Date:  1996-06       Impact factor: 3.584

6.  Does the excitatory amino acid receptor antagonist 2-APH exhibit anxiolytic activity?

Authors:  D N Stephens; B S Meldrum; R Weidmann; C Schneider; M Grützner
Journal:  Psychopharmacology (Berl)       Date:  1986       Impact factor: 4.530

7.  Unilateral up-regulation of glutamate receptors in limbic regions of amygdaloid-kindled rats.

Authors:  M Cincotta; N A Young; P M Beart
Journal:  Exp Brain Res       Date:  1991       Impact factor: 1.972

8.  Effects of an N-methyl-D-aspartate receptor agonist and its antagonist CPP on the levels of dopamine and serotonin metabolites in rat striatum collected in vivo by using a brain dialysis technique.

Authors:  H Kabuto; I Yokoi; K Mizukawa; A Mori
Journal:  Neurochem Res       Date:  1989-11       Impact factor: 3.996

Review 9.  Glutamate in the mammalian CNS.

Authors:  S Sahai
Journal:  Eur Arch Psychiatry Clin Neurosci       Date:  1990       Impact factor: 5.270

Review 10.  Phencyclidine. Physiological actions, interactions with excitatory amino acids and endogenous ligands.

Authors:  P C Contreras; J B Monahan; T H Lanthorn; L M Pullan; D A DiMaggio; G E Handelmann; N M Gray; T L O'Donohue
Journal:  Mol Neurobiol       Date:  1987       Impact factor: 5.590
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