Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 The gating of single calcium-dependent potassium channels is described by an activation/blockade mechanism.

Literature DB >> 6293598

The gating of single calcium-dependent potassium channels is described by an activation/blockade mechanism.

Abstract

Single calcium dependent potassium channels from cultured rat myoballs have been studied with the patch clamp technique, and current records subjected to statistical analysis. From the dependence of the mean open state probability on the internal calcium concentration, two calcium ions are required to open the channel. The open state and closed state lifetime distributions reveal that the usual activation model is not applicable to these channels. They are consistent with a two step gating mechanism that involves both activation by calcium and blockade by a calcium-sensitive gate.

Entities: Chemical Species

Mesh：

Substances：

Year: 1982 PMID： 6293598 DOI： 10.1007/bf00536014

Source DB: PubMed Journal: Biophys Struct Mech ISSN： 0340-1057

22 in total

Review 1. Calcium-dependent potassium activation in nervous tissues.

Authors: R W Meech
Journal: Annu Rev Biophys Bioeng Date: 1978

2. Rapid kinetics of single glutamate-receptor channels.

Authors: S G Cull-Candy; I Parker
Journal: Nature Date: 1982-02-04 Impact factor: 49.962

3. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches.

Authors: O P Hamill; A Marty; E Neher; B Sakmann; F J Sigworth
Journal: Pflugers Arch Date: 1981-08 Impact factor: 3.657

4. Single channel recordings of Ca2+-activated K+ currents in rat muscle cell culture.

Authors: B S Pallotta; K L Magleby; J N Barrett
Journal: Nature Date: 1981-10-08 Impact factor: 49.962

Review 5. Acetylcholine receptor kinetics.

Authors: P R Adams
Journal: J Membr Biol Date: 1981-02-28 Impact factor: 1.843

5. Large conductance ca-activated k channels in smooth muscle cell membrane: reduction in unitary currents due to internal na ions.

Authors: J J Singer; J V Walsh
Journal: Biophys J Date: 1984-01 Impact factor: 4.033

10. Characterization of calcium-activated potassium channels in single smooth muscle cells using the patch-clamp technique.

Authors: J J Singer; J V Walsh
Journal: Pflugers Arch Date: 1987-02 Impact factor: 3.657

The gating of single calcium-dependent potassium channels is described by an activation/blockade mechanism.

Review 1. Calcium-dependent potassium activation in nervous tissues.

2. Rapid kinetics of single glutamate-receptor channels.

3. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches.

4. Single channel recordings of Ca2+-activated K+ currents in rat muscle cell culture.

Review 5. Acetylcholine receptor kinetics.

6. Ca-dependent K channels with large unitary conductance in chromaffin cell membranes.

7. Intracellular Ca2+ activates a fast voltage-sensitive K+ current in vertebrate sympathetic neurones.

8. Ca2+-activated K+ channels in erythrocytes and excitable cells.

9. Single acetylcholine-activated channels show burst-kinetics in presence of desensitizing concentrations of agonist.

10. Single glutamate-activated channels recorded from locust muscle fibres with perfused patch-clamp electrodes.

1. Complex voltage-dependent behavior of single unliganded calcium-sensitive potassium channels.

2. Ca2+-dependent gating mechanisms for dSlo, a large-conductance Ca2+-activated K+ (BK) channel.

3. Allosteric gating of a large conductance Ca-activated K+ channel.

4. Conduction, Blockade and Gating in a Ca -activated K Channel Incorporated into Planar Lipid Bilayers.

5. Large conductance ca-activated k channels in smooth muscle cell membrane: reduction in unitary currents due to internal na ions.

Review 6. Calcium-activated potassium channels: regulation by calcium.

7. Ca2+-activated K+ permeability in human erythrocytes: modulation of single-channel events.

8. Single-channel analysis of a potassium inward rectifier in myocytes of newborn rat heart.

9. A general solution to the time interval omission problem applied to single channel analysis.

10. Characterization of calcium-activated potassium channels in single smooth muscle cells using the patch-clamp technique.