Literature DB >> 6293511

Inhibition of a high affinity cyclic AMP phosphodiesterase and relaxation of canine tracheal smooth muscle.

J B Polson, J J Krzanowski, A Szentivanyi.   

Abstract

The cyclic nucleotide phosphodiesterase (PDE) activity of canine tracheal smooth muscle (CTS,) was examined. Column chromatography of soluble CTSM-PDE revealed five peaks of activity. One of these peaks (V) was examined further in this study and showed a high affinity for adenosine 3',5'-cyclic monophosphate (Km = 0.63 microM). Seven pharmacological PDE inhibitors were tested for their abilities to inhibit the peak V enzyme and also for their abilities to cause mechanical relaxation of CTSM strips in isolated tissue baths. A strong correlation (P greater than 0.001) between peak V PDE inhibition (-log Ki) and airway muscle relaxation (-log ED50) was found.

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Year:  1982        PMID： 6293511     DOI： 10.1016/0006-2952(82)90618-9

Source DB:  PubMed          Journal:  Biochem Pharmacol        ISSN： 0006-2952            Impact factor:   5.858


  8 in total

1.  Quantification of theophylline-induced eosinopenia and hypokalaemia in healthy volunteers.

Authors:  M C Braat; R E Jonkers; E H Bel; C J Van Boxtel
Journal:  Clin Pharmacokinet       Date:  1992-03       Impact factor: 6.447

Review 2.  Phosphodiesterase inhibitors: new opportunities for the treatment of asthma.

Authors:  T J Torphy; B J Undem
Journal:  Thorax       Date:  1991-07       Impact factor: 9.139

3.  Phosphodiesterase 4 inhibitor rolipram potentiates the inhibitory effect of calcitonin on osteoclastogenesis.

Authors:  Ken-ichi Miyamoto; Tatsuo Nishioka; Yoshihiro Waki; Masaaki Nomura; Hiromu Katsuta; Koichi Yokogawa; Hitoshi Amano
Journal:  J Bone Miner Metab       Date:  2006       Impact factor: 2.626

4.  Effects of phosphodiesterase inhibitors on normal and chemically-skinned isolated airway smooth muscle.

Authors:  S E Bryson; I W Rodger
Journal:  Br J Pharmacol       Date:  1987-11       Impact factor: 8.739

5.  Comparative effects of BRL 38227, nitrendipine and isoprenaline on carbachol- and histamine-stimulated phosphoinositide metabolism in airway smooth muscle.

Authors:  R A Challiss; N Patel; J R Arch
Journal:  Br J Pharmacol       Date:  1992-04       Impact factor: 8.739

6.  Caffeine acting on pregnant rat myometrium: analysis of its relaxant action and its failure to release Ca2+ from intracellular stores.

Authors:  J P Savineau; J Mironneau
Journal:  Br J Pharmacol       Date:  1990-02       Impact factor: 8.739

7.  Role of phosphodiesterase isoenzymes in regulating intracellular cyclic AMP in adenosine-stimulated smooth muscle cells.

Authors:  Y Xiong; E W Westhead; L L Slakey
Journal:  Biochem J       Date:  1995-01-15       Impact factor: 3.857

8.  The Use of Antiallergic and Antiasthmatic Drugs in Viral Infections of the Upper Respiratory Tract.

Authors:  Nils Åberg
Journal:  Clin Immunother       Date:  2012-11-18
  8 in total

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