Literature DB >> 6293377

Synergistic activities of type I (alpha, beta) and type II (gamma) murine interferons.

A Zerial, A G Hovanessian, S Stefanos, K Huygen, G H Werner, E Falcoff.   

Abstract

Type I (alpha, beta) and type II (gamma) murine interferons are able to potentiate each other with respect to the inhibition of encephalomyocarditis (EMC) virus and of herpes simplex virus type 1 (HSV-1) multiplication in a murine cell line (DBT). Examination of two double-stranded RNA-dependent enzymes in DBT cells, the 2-5A synthetase and the 67,000 MW protein phosphokinase indicates that mixed interferon preparations act synergistically at least with respect to an increase in the activity of the former enzyme. The results obtained with gamma interferons of different origin and of different specific activity suggest that interferon itself, rather than the lymphokines present in the interferon preparations, is responsible for the synergistic effect.

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Year:  1982        PMID： 6293377     DOI： 10.1016/0166-3542(82)90045-6

Source DB:  PubMed          Journal:  Antiviral Res        ISSN： 0166-3542            Impact factor:   5.970


  13 in total

1.  DNA protein interactions at the interferon-responsive promoter elements: potential for an H-DNA conformation.

Authors:  C Roy; B Lebleu
Journal:  Nucleic Acids Res       Date:  1991-02-11       Impact factor: 16.971

2.  Posttranscriptional regulation of beta interferon expression in erythroid Friend cells treated with gamma interferon.

Authors:  G Marziali; G Fiorucci; E M Coccia; Z Percario; J Raber; A Battistini; G B Rossi; E Affabris; G Romeo
Journal:  J Virol       Date:  1991-08       Impact factor: 5.103

3.  Image-guided modeling of virus growth and spread.

Authors:  Eric L Haseltine; Vy Lam; John Yin; James B Rawlings
Journal:  Bull Math Biol       Date:  2008-04-25       Impact factor: 1.758

4.  Beta and gamma interferons act synergistically to produce an antiviral state in cells resistant to both interferons individually.

Authors:  J A Lewis; A Huq; B Shan
Journal:  J Virol       Date:  1989-11       Impact factor: 5.103

5.  2'-5' oligo-A-synthetase activity in bovine peripheral blood leukocytes and alveolar macrophages exposed to recombinant interferons and tumor necrosis factor-alpha.

Authors:  H B Ohmann; M Campos; P J Griebel; L A Babiuk
Journal:  Can J Vet Res       Date:  1989-04       Impact factor: 1.310

Review 6.  Alpha interferon: a look to the future.

Authors:  E M Bonnem
Journal:  Invest New Drugs       Date:  1987       Impact factor: 3.850

Review 7.  Interferons, a group of multiple lymphokines.

Authors:  H Kirchner
Journal:  Springer Semin Immunopathol       Date:  1984

8.  Synergistic antiviral and antiproliferative activities of Escherichia coli-derived human alpha, beta, and gamma interferons.

Authors:  C W Czarniecki; C W Fennie; D B Powers; D A Estell
Journal:  J Virol       Date:  1984-02       Impact factor: 5.103

9.  Alpha/Beta interferon and gamma interferon synergize to inhibit the replication of herpes simplex virus type 1.

Authors:  Bruno Sainz; William P Halford
Journal:  J Virol       Date:  2002-11       Impact factor: 5.103

10.  Importance of interferons in recovery from mousepox.

Authors:  G Karupiah; T N Fredrickson; K L Holmes; L H Khairallah; R M Buller
Journal:  J Virol       Date:  1993-07       Impact factor: 5.103
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