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Literature DB >> 6292833

Structure-function relationship of Rous sarcoma virus leader RNA.

Abstract

Cells infected by RSV synthesize viral 35S RNA as well as subgenomic 28S and 22S RNAs coding for the Env and Src genes respectively. In addition, at least the 5' 101 nucleotides of the leader are also conserved and we have shown previously that this sequence contains a strong ribosome binding site (J.-L. Darlix et al., J. Virol. 29, 597). We now report the RNA sequence of Rous Sarcoma virus (RSV) leader RNA and propose a folding of this 5' untranslated region which brings the Cap, the initiation codon for Gag and the strong ribosome binding site close to each other. We also show that ribosomes protect a sequence just upstream from initiator Aug of Gag in vitro, and believed to interact with part of the strong ribosome binding site according to the folding proposed for the leader RNA.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1982 PMID： 6292833 PMCID： PMC320864 DOI： 10.1093/nar/10.17.5183

Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971

23 in total

1. Stimultaneous purification of Escherichia coli termination factor rho, RNAase III and RNAase H.

Authors: J L Darlix
Journal: Eur J Biochem Date: 1975-02-21

2. Nucleotide sequence that binds primer for DNA synthesis to the avian sarcoma virus genome.

Authors: B Cordell; E Stavnezer; R Friedrich; J M Bishop; H M Goodman
Journal: J Virol Date: 1976-08 Impact factor: 5.103

3. The size and genetic composition of virus-specific RNAs in the cytoplasm of cells producing avian sarcoma-leukosis viruses.

Authors: S R Weiss; H E Varmus; J M Bishop
Journal: Cell Date: 1977-12 Impact factor: 41.582

4. New rapid gel sequencing method for RNA.

Authors: A Simoncsits; G G Brownlee; R S Brown; J R Rubin; H Guilley
Journal: Nature Date: 1977-10-27 Impact factor: 49.962

5. Structure-function relationship of 5' non-coding sequence of rabbit alpha- and beta-globin mRNA.

Authors: F E Baralle
Journal: Nature Date: 1977-05-19 Impact factor: 49.962

6. A new method for sequencing DNA.

Authors: A M Maxam; W Gilbert
Journal: Proc Natl Acad Sci U S A Date: 1977-02 Impact factor: 11.205

7. Preparative two-dimensional polyacrylamide gel electrophoresis of 32 P-labeled RNA.

Authors: R de Wachter; W Fiers
Journal: Anal Biochem Date: 1972-09 Impact factor: 3.365

8. Sequence of a ribosome binding site in bacteriophage Q-beta-RNA.

Authors: J Hindley; D H Staples
Journal: Nature Date: 1969-12-06 Impact factor: 49.962

9. Polypeptide chain initiation: nucleotide sequences of the three ribosomal binding sites in bacteriophage R17 RNA.

Authors: J A Steitz
Journal: Nature Date: 1969-12-06 Impact factor: 49.962

10. Mapping adenines, guanines, and pyrimidines in RNA.

Authors: H Donis-Keller; A M Maxam; W Gilbert
Journal: Nucleic Acids Res Date: 1977-08 Impact factor: 16.971

34 in total

1. Rous sarcoma virus translation revisited: characterization of an internal ribosome entry segment in the 5' leader of the genomic RNA.

Authors: C Deffaud; J L Darlix
Journal: J Virol Date: 2000-12 Impact factor: 5.103

2. A comparison of eukaryotic viral 5'-leader sequences as enhancers of mRNA expression in vivo.

Authors: D R Gallie; D E Sleat; J W Watts; P C Turner; T M Wilson
Journal: Nucleic Acids Res Date: 1987-11-11 Impact factor: 16.971

3. Overlapping retrovirus U5 sequence elements are required for efficient integration and initiation of reverse transcription.

Authors: D Cobrinik; A Aiyar; Z Ge; M Katzman; H Huang; J Leis
Journal: J Virol Date: 1991-07 Impact factor: 5.103

Structure-function relationship of Rous sarcoma virus leader RNA.

1. Stimultaneous purification of Escherichia coli termination factor rho, RNAase III and RNAase H.

2. Nucleotide sequence that binds primer for DNA synthesis to the avian sarcoma virus genome.

3. The size and genetic composition of virus-specific RNAs in the cytoplasm of cells producing avian sarcoma-leukosis viruses.

4. New rapid gel sequencing method for RNA.

5. Structure-function relationship of 5' non-coding sequence of rabbit alpha- and beta-globin mRNA.

6. A new method for sequencing DNA.

7. Preparative two-dimensional polyacrylamide gel electrophoresis of 32 P-labeled RNA.

8. Sequence of a ribosome binding site in bacteriophage Q-beta-RNA.

9. Polypeptide chain initiation: nucleotide sequences of the three ribosomal binding sites in bacteriophage R17 RNA.

10. Mapping adenines, guanines, and pyrimidines in RNA.

1. Rous sarcoma virus translation revisited: characterization of an internal ribosome entry segment in the 5' leader of the genomic RNA.

2. A comparison of eukaryotic viral 5'-leader sequences as enhancers of mRNA expression in vivo.

3. Overlapping retrovirus U5 sequence elements are required for efficient integration and initiation of reverse transcription.

4. A model for the expression of CaMV nucleic acid.

5. A study of the dimer formation of Rous sarcoma virus RNA and of its effect on viral protein synthesis in vitro.

6. Inhibition of avian retrovirus protein synthesis in the presence of host cellular mRNA.

7. Characterization of ribosome binding on Rous sarcoma virus RNA in vitro.

8. Unusual features of the leader sequence of Rous sarcoma virus packaging mutant TK15.

9. Role of the avian retrovirus mRNA leader in expression: evidence for novel translational control.

10. Minimal sequence requirements of a functional human immunodeficiency virus type 1 primer binding site.