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Literature DB >> 6292603

Corticotropin-releasing factor stimulants adenylate cyclase activity in the anterior pituitary gland.

Abstract

Ovine corticotropin-releasing factor (CRF) stimulates adenylate cyclase activity in rat anterior pituitary homogenate at an ED50 value of 70 nM. GTP increases the stimulatory effect of CRF on ]32p] cyclic AMP formation in a rat adenohypophysial particulate fraction and in bovine anterior pituitary plasma membranes. The present data show that CRF stimulates adenylate cyclase activity in the anterior pituitary gland at least partly through a guanyl nucleotide-dependent mechanism.

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Year: 1982 PMID： 6292603 DOI： 10.1016/0024-3205(82)90085-6

Source DB: PubMed Journal: Life Sci ISSN： 0024-3205 Impact factor: 5.037

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Cited

6 in total

1. Multiple factors involved in the control of ACTH secretion.

Authors: L Proulx; V Giguère; J Côté; F Labrie
Journal: J Endocrinol Invest Date: 1984-06 Impact factor: 4.256

2. Stimulation of the hypothalamo-pituitary-adrenal axis in the rat by the type 4 phosphodiesterase (PDE-4) inhibitor, denbufylline.

Authors: A J Hadley; M Kumari; P O Cover; J Osborne; R Poyser; J D Flack; J C Buckingham
Journal: Br J Pharmacol Date: 1996-10 Impact factor: 8.739

3. Region-specific regulation of RGS4 (Regulator of G-protein-signaling protein type 4) in brain by stress and glucocorticoids: in vivo and in vitro studies.

Authors: Y G Ni; S J Gold; P A Iredale; R Z Terwilliger; R S Duman; E J Nestler
Journal: J Neurosci Date: 1999-05-15 Impact factor: 6.167

Corticotropin-releasing factor stimulants adenylate cyclase activity in the anterior pituitary gland.

1. Multiple factors involved in the control of ACTH secretion.

2. Stimulation of the hypothalamo-pituitary-adrenal axis in the rat by the type 4 phosphodiesterase (PDE-4) inhibitor, denbufylline.

3. Region-specific regulation of RGS4 (Regulator of G-protein-signaling protein type 4) in brain by stress and glucocorticoids: in vivo and in vitro studies.

Review 4. The role of intracellular messengers in adrenocorticotropin secretion in vitro.

5. Effects of atrial natriuretic factor on anterior pituitary hormone secretion in normal man.

6. Colorimetric assay for rapid screening of corticotropin releasing factor receptor ligands.