Literature DB >> 6292212

A lymphoma protein with an in vitro site of tyrosine phosphorylation homologous to that in pp60src.

J E Casnellie, M L Harrison, K E Hellstrom, E G Krebs.   

Abstract

The major in vitro substrate for a tyrosine protein kinase in the particulate fraction of the lymphoma cell line LSTRA is a protein of molecular weight of 58,000 (pp58) (Casnellie, J. E. Harrison, M. L., Pike, L. J., Hellstrom, K. E., and Krebs, E. G. (1982) Proc. Natl. Acad. Sci. U. S. A. 79, 282-286). In order to determine if this protein was related to pp60src, the transformation-specific protein from Rous sarcoma virus, partial proteolysis maps of in vitro 32P-labeled pp58 and pp60src were prepared using Staphylococcus aureus V8 protease and papain. The maps were clearly different, indicating the pp58 is distinct from pp60src. However characterization of the tryptic fragment containing the single site of in vitro tyrosine phosphorylation in pp58 has revealed that the amino acid sequence around this site is extremely homologous to, if not identical with the sequence around the site of tyrosine phosphorylation in pp60src.

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Year:  1982        PMID： 6292212

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  16 in total

1.  Purification and initial characterization of the lymphoid-cell protein-tyrosine kinase p56lck from a baculovirus expression system.

Authors:  S E Ramer; D G Winkler; A Carrera; T M Roberts; C T Walsh
Journal:  Proc Natl Acad Sci U S A       Date:  1991-07-15       Impact factor: 11.205

2.  The carboxy-terminal sequence of p56lck can regulate p60c-src.

Authors:  A MacAuley; J A Cooper
Journal:  Mol Cell Biol       Date:  1988-08       Impact factor: 4.272

3.  Cross-linking of T-cell surface molecules CD4 and CD8 stimulates phosphorylation of the lck tyrosine protein kinase at the autophosphorylation site.

Authors:  K X Luo; B M Sefton
Journal:  Mol Cell Biol       Date:  1990-10       Impact factor: 4.272

4.  Phosphorylation at a tyrosine residue of lipomodulin in mitogen-stimulated murine thymocytes.

Authors:  F Hirata; K Matsuda; Y Notsu; T Hattori; R del Carmine
Journal:  Proc Natl Acad Sci U S A       Date:  1984-08       Impact factor: 11.205

5.  Identification of the tyrosine protein kinase from LSTRA cells by use of site-specific antibodies.

Authors:  J E Casnellie; L E Gentry; L R Rohrschneider; E G Krebs
Journal:  Proc Natl Acad Sci U S A       Date:  1984-11       Impact factor: 11.205

6.  Antipeptide antiserum identifies a widely distributed cellular tyrosine kinase related to but distinct from the c-fps/fes-encoded protein.

Authors:  R A Feldman; J P Tam; H Hanafusa
Journal:  Mol Cell Biol       Date:  1986-04       Impact factor: 4.272

7.  Evidence from two transformed cell lines that the phosphorylations of peptide tyrosine and phosphatidylinositol are catalyzed by different proteins.

Authors:  M L MacDonald; E A Kuenzel; J A Glomset; E G Krebs
Journal:  Proc Natl Acad Sci U S A       Date:  1985-06       Impact factor: 11.205

8.  Tyrosine phosphorylation of a c-Src-like protein is increased in membranes of CD4- CD8- T lymphocytes from lpr/lpr mice.

Authors:  T Katagiri; J P Ting; R Dy; C Prokop; P Cohen; H S Earp
Journal:  Mol Cell Biol       Date:  1989-11       Impact factor: 4.272

9.  Activated lck tyrosine protein kinase stimulates antigen-independent interleukin-2 production in T cells.

Authors:  K Luo; B M Sefton
Journal:  Mol Cell Biol       Date:  1992-10       Impact factor: 4.272

10.  Characterization of the protein apparently responsible for the elevated tyrosine protein kinase activity in LSTRA cells.

Authors:  A F Voronova; J E Buss; T Patschinsky; T Hunter; B M Sefton
Journal:  Mol Cell Biol       Date:  1984-12       Impact factor: 4.272
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