Literature DB >> 6292151

Studies on bacterial cell wall inhibitors. X. Properties of phosph-N-acetylmuramoyl-pentapeptide-transferase in peptidoglycan synthesis of Bacillus megaterium and its inhibition by amphomycin.

H Tanaka, R Oiwa, S Matsukura, J Inokoshi, S Omura.   

Abstract

The phospho-N-acetylmuramoyl-pentapeptide-transferase from Bacillus megaterium KM was characterized by the transfer reaction. The particulate enzyme preparation had the activity to transfer phospho-N-acetylmuramoyl-pentapeptide from UDP-N-acetylmuramoyl-pentapeptide to undecaprenoid-1-ol-phosphate. The optimum pH for activity was about 8.5. The reaction required the presence of Mg2+ and an SH-protector. With 25 mm Mg2+ the maximum activity was observed. The reaction was reversible and so the addition of UMP decreased the formation of undecaprenoid-1-ol-diphospho-N-acetylmuramoyl-pentapeptide. Amphomycin inhibited non-competitively the transferase for the substrate UDP-N-acetylmuramoyl-pentapeptide.

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Year:  1982        PMID： 6292151     DOI： 10.7164/antibiotics.35.1216

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  5 in total

1.  Sequencing and analysis of the biosynthetic gene cluster of the lipopeptide antibiotic Friulimicin in Actinoplanes friuliensis.

Authors:  C Müller; S Nolden; P Gebhardt; E Heinzelmann; C Lange; O Puk; K Welzel; W Wohlleben; D Schwartz
Journal:  Antimicrob Agents Chemother       Date:  2007-01-12       Impact factor: 5.191

2.  Isolation and structure elucidation of lipopeptide antibiotic taromycin B from the activated taromycin biosynthetic gene cluster.

Authors:  Kirk A Reynolds; Hanna Luhavaya; Jie Li; Samira Dahesh; Victor Nizet; Kazuya Yamanaka; Bradley S Moore
Journal:  J Antibiot (Tokyo)       Date:  2017-11-29       Impact factor: 2.649

3.  Molecular cloning and identification of the laspartomycin biosynthetic gene cluster from Streptomyces viridochromogenes.

Authors:  Yang Wang; Ying Chen; Qirong Shen; Xihou Yin
Journal:  Gene       Date:  2011-05-27       Impact factor: 3.688

4.  Mechanism of action and limited cross-resistance of new lipopeptide MX-2401.

Authors:  E Rubinchik; T Schneider; M Elliott; W R P Scott; J Pan; C Anklin; H Yang; D Dugourd; A Müller; K Gries; S K Straus; H G Sahl; R E W Hancock
Journal:  Antimicrob Agents Chemother       Date:  2011-04-04       Impact factor: 5.191

5.  The lipopeptide antibiotic Friulimicin B inhibits cell wall biosynthesis through complex formation with bactoprenol phosphate.

Authors:  T Schneider; K Gries; M Josten; I Wiedemann; S Pelzer; H Labischinski; H-G Sahl
Journal:  Antimicrob Agents Chemother       Date:  2009-01-21       Impact factor: 5.191
  5 in total

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