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Literature DB >> 6291893

A serotonin agonist-antagonist reversible effect on Na+-K+-ATPase activity in the developing rat brain.

Abstract

In brain of adult and developing rats the Na+-K+-adenosine triphosphatase (Na+-K+-ATPase) system seems to react to serotonin (5-HT) changes induced pharmacologically. A 5-HT agonist (quipazine) elicits a response of the enzyme activity in the cerebral cortex in vivo, which is neutralized with a 5-HT antagonist (methysergide). This effect was observed from day 21 to adulthood. Also in a state of 5-HT receptor hypersensitivity (rats treated early with 5,6-dihydroxytryptamine), the response of Na+-K+-ATPase to the 5-HT agonist was higher than without neurotoxic lesion of 5-HT paths. These data suggest an involvement of the Na+-K+-ATPase system in 5-HT receptor sensitivity in the rat brain.

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Year: 1982 PMID： 6291893 DOI： 10.1159/000112692

Source DB: PubMed Journal: Dev Neurosci ISSN： 0378-5866 Impact factor: 2.984

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Cited

7 in total

1. Regulation of glial Na+/K+-ATPase by serotonin: identification of participating receptors.

Authors: M T Peña-Rangel; R Mercado; J Hernández-Rodríguez
Journal: Neurochem Res Date: 1999-05 Impact factor: 3.996

2. Assessment of oxidative damage induced by acute doses of morphine sulfate in postnatal and adult rat brain.

Authors: David Calderón Guzmán; Ivonne Espítia Vázquez; Norma Osnaya Brizuela; Raquel García Alvarez; Gerardo Barragán Mejía; Ernestina Hernández García; Daniel Santamaría; Mario la Rosa de Apreza; Hugo Juárez Olguín
Journal: Neurochem Res Date: 2006-05-09 Impact factor: 3.996

A serotonin agonist-antagonist reversible effect on Na+-K+-ATPase activity in the developing rat brain.

1. Regulation of glial Na+/K+-ATPase by serotonin: identification of participating receptors.

2. Assessment of oxidative damage induced by acute doses of morphine sulfate in postnatal and adult rat brain.

3. Serotonin modulation of low-affinity ouabain binding in rat brain determined by quantitative autoradiography.

4. Functional role of sodium pump in human placental arteries.

5. Protective Effect of Bacoside-A against Morphine-Induced Oxidative Stress in Rats.

6. Assessment of antioxidant effect of 2,5-dihydroxybenzoic acid and vitamin a in brains of rats with induced hyperoxia.

Review 7. Na⁺/K⁺-pump and neurotransmitter membrane receptors.

A serotonin agonist-antagonist reversible effect on Na+-K+-ATPase activity in the developing rat brain.

1. Regulation of glial Na+/K+-ATPase by serotonin: identification of participating receptors.

2. Assessment of oxidative damage induced by acute doses of morphine sulfate in postnatal and adult rat brain.

3. Serotonin modulation of low-affinity ouabain binding in rat brain determined by quantitative autoradiography.

4. Functional role of sodium pump in human placental arteries.

5. Protective Effect of Bacoside-A against Morphine-Induced Oxidative Stress in Rats.

6. Assessment of antioxidant effect of 2,5-dihydroxybenzoic acid and vitamin a in brains of rats with induced hyperoxia.

Review 7. Na+/K+-pump and neurotransmitter membrane receptors.

Review 7. Na⁺/K⁺-pump and neurotransmitter membrane receptors.