Literature DB >> 6291721

Sodium valproate enhances responses to GABA receptor activation only at high concentrations.

N L Harrison, M A Simmonds.   

Abstract

Sodium valproate (VPA) enhanced muscimol-induced depolarizations of rat cuneate afferent fibres, but only at millimolar concentrations. VPA (10 mM) also reduced the potency of picrotoxin as an antagonist of muscimol without affecting that of bicuculline. These findings are discussed in relation to the anticonvulsant properties and potency of VPA.

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Year:  1982        PMID： 6291721     DOI： 10.1016/0006-8993(82)90971-4

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  8 in total

1.  Microionophoretic study with milacemide, a glycine precursor, on mammalian central nervous system cells.

Authors:  J M Godfraind
Journal:  Br J Pharmacol       Date:  1990-05       Impact factor: 8.739

2.  Role of GABAergic activity of sodium valproate against ischemia-reperfusion-induced acute kidney injury in rats.

Authors:  Ramanpreet Brar; Jaswinder Pal Singh; Tajpreet Kaur; Saroj Arora; Amrit Pal Singh
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2013-10-24       Impact factor: 3.000

3.  Inhibition of quisqualate-induced seizures by glutamic acid diethyl ester and anti-epileptic drugs.

Authors:  S S Schwarz; W J Freed
Journal:  J Neural Transm       Date:  1986       Impact factor: 3.575

Review 4.  Effects of the antiepileptic drug valproate on metabolism and function of inhibitory and excitatory amino acids in the brain.

Authors:  W Löscher
Journal:  Neurochem Res       Date:  1993-04       Impact factor: 3.996

5.  "In vivo" administration of valproate decreases t-[35S]butylbicyclophosphorothionate binding in the rat brain.

Authors:  A Concas; M P Mascia; E Sanna; G Santoro; M Serra; G Biggio
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1991-03       Impact factor: 3.000

6.  Suppression of preoptic GABA release caused by push-pull-perfusion with sodium valproate.

Authors:  R Wolf; U Tscherne; H M Emrich
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1988-12       Impact factor: 3.000

7.  Valproate enhances GABA-A mediated inhibition of locus coeruleus neurones in vitro.

Authors:  H R Olpe; M W Steinmann; M F Pozza; F Brugger; M Schmutz
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1988-12       Impact factor: 3.000

8.  An RNAi-mediated screen identifies novel targets for next-generation antiepileptic drugs based on increased expression of the homeostatic regulator pumilio.

Authors:  Wei-Hsiang Lin; Miaomiao He; Yuen Ngan Fan; Richard A Baines
Journal:  J Neurogenet       Date:  2018-05-02       Impact factor: 1.250
  8 in total

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