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Literature DB >> 6291689

Frequency-dependent depression of ganglionic transmission by propranolol and diltiazem in the superior cervical ganglion of the guinea-pig.

Abstract

1 Effects of propranolol and diltiazem on ganglionic transmission in the superior cervical ganglion of the guinea-pig were investigated with intracellular recording techniques. 2 Propranolol and diltiazem (5 X 10(-6)-10(-5) M) induced a transmission failure in the ganglion upon preganglionic nerve stimulation at high frequency (25-30 Hz) without affecting action potentials induced by direct stimulation of the soma membrane, or potentials induced by iontophoretically applied acetylecholine. 3 The results suggest that propranolol and diltiazem may act on preganglionic nerve terminals to inhibit Ca2+ influx in a frequency-dependent manner. These agents may depress excess sympathetic activity without much affecting normal ganglionic transmission.

Entities: Chemical Disease Species

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Year: 1982 PMID： 6291689 PMCID： PMC2044597 DOI： 10.1111/j.1476-5381.1982.tb09305.x

Source DB: PubMed Journal: Br J Pharmacol ISSN： 0007-1188 Impact factor: 8.739

21 in total

1. Ca-dependent action potential.

Authors: S Hagiwara
Journal: Membranes Date: 1975

2. Effect of verapamil on the noraml action potential and on a calcium-dependent slow response of canine cardiac Purkinje fibers.

Authors: P F Cranefield; R S Aronson; A L Wit
Journal: Circ Res Date: 1974-02 Impact factor: 17.367

3. Differentiation of the transmembrane Na and Ca channels in mammalian cardiac fibres by the use of specific inhibitors.

Authors: M Kohlhardt; B Bauer; H Krause; A Fleckenstein
Journal: Pflugers Arch Date: 1972 Impact factor: 3.657

4. Intracellular recording from mammalian superior cervical ganglion in situ.

Authors: S D Erulkar; J K Woodward
Journal: J Physiol Date: 1968-11 Impact factor: 5.182

5. Transmitter release induced by injection of calcium ions into nerve terminals.

Authors: R Miledi
Journal: Proc R Soc Lond B Biol Sci Date: 1973-07-03

6. Actions of beta-blocking agents on membrane excitability of the lobster giant axon.

Authors: M Sasa; B P Avner; E X Albuquerque
Journal: Eur J Pharmacol Date: 1973-07 Impact factor: 4.432

7. Inotropic and electrophysiological actions of verapamil and D 600 in mammalian myocardium. II. Pattern of inotropic effects of the optical isomers.

Authors: R Bayer; R Kaufmann; R Mannhold
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1975 Impact factor: 3.000

Frequency-dependent depression of ganglionic transmission by propranolol and diltiazem in the superior cervical ganglion of the guinea-pig.

1. Ca-dependent action potential.

2. Effect of verapamil on the noraml action potential and on a calcium-dependent slow response of canine cardiac Purkinje fibers.

3. Differentiation of the transmembrane Na and Ca channels in mammalian cardiac fibres by the use of specific inhibitors.

4. Intracellular recording from mammalian superior cervical ganglion in situ.

5. Transmitter release induced by injection of calcium ions into nerve terminals.

6. Actions of beta-blocking agents on membrane excitability of the lobster giant axon.

7. Inotropic and electrophysiological actions of verapamil and D 600 in mammalian myocardium. II. Pattern of inotropic effects of the optical isomers.

8. An electrophysiological analysis of the storage and release of noradrenaline at sympathetic nerve terminals.

9. Site of adrenaline blockade in the superior cervical ganglion of the rabbit.

10. A study of synaptic transmission in the absence of nerve impulses.

1. Strychnine decreases the voltage-dependent Ca2+ current of both Aplysia and frog ganglion neurons.

2. [Hemodynamic interferences between diltiazem and thiopental--experimental study in the pig].