Literature DB >> 6291385

Accelerated loss of FEV- in polyurethane production workers: a four-year prospective study.

D H Wegman, A W Musk, D M Main, L D Pagnotto.   

Abstract

A four-year longitudinal study of ventilatory function in polyurethane-foam production workers exposed to toluene diisocyanate (TDI) revealed a dose-response relationship between average exposure to TDI and change in forced expiratory volume per second (FEV-1). Workers with mean exposure in excess of 0.0035 ppm showed a greater rate of decline of FEV-1 over the four-year period than that expected from aging. Factors other than TDI exposure (sex, smoking history, history of atopy) do not account for the loss. The current threshold limit value (TLV) for exposure to TDI in industry (0.02 ppm) does not protect workers from accelerated impairment of ventilatory capacity.

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Year:  1982        PMID： 6291385     DOI： 10.1002/ajim.4700030212

Source DB:  PubMed          Journal:  Am J Ind Med        ISSN： 0271-3586            Impact factor:   2.214


  10 in total

1.  Inception cohort study of workers exposed to toluene diisocyanate at a polyurethane foam factory: initial one-year follow-up.

Authors:  Wei Gui; Adam V Wisnewski; Iulia Neamtiu; Eugen Gurzau; Judith A Sparer; Meredith H Stowe; Jian Liu; Martin D Slade; Olivia A Rusu; Carrie A Redlich
Journal:  Am J Ind Med       Date:  2014-09-29       Impact factor: 2.214

2.  Biological monitoring of isocyanates and related amines. IV. 2,4- and 2,6-toluenediamine in hydrolysed plasma and urine after test-chamber exposure of humans to 2,4- and 2,6-toluene diisocyanate.

Authors:  T Brorson; G Skarping; C Sangö
Journal:  Int Arch Occup Environ Health       Date:  1991       Impact factor: 3.015

3.  Symptoms and lung function in low-exposure to TDI by polyurethane foam manufacturing.

Authors:  R Alexandersson; G Hedenstierna; E Randma; G Rosen; A Swenson; G Tornling
Journal:  Int Arch Occup Environ Health       Date:  1985       Impact factor: 3.015

Review 4.  The potential impact of epidemiology on the prevention of occupational disease.

Authors:  D H Wegman
Journal:  Am J Public Health       Date:  1992-07       Impact factor: 9.308

5.  Biological monitoring of occupational exposure to toluene diisocyanate.

Authors:  A Maître; M Berode; A Perdrix; S Romazini; H Savolainen
Journal:  Int Arch Occup Environ Health       Date:  1993       Impact factor: 3.015

6.  Biological monitoring of occupational exposure to toluene diisocyanate: measurement of toluenediamine in hydrolysed urine and plasma by gas chromatography-mass spectrometry.

Authors:  P Persson; M Dalene; G Skarping; M Adamsson; L Hagmar
Journal:  Br J Ind Med       Date:  1993-12

7.  Diurnal variation in peak expiratory flow rate among workers exposed to toluene diisocyanate in the polyurethane foam manufacturing industry.

Authors:  H S Lee; W H Phoon
Journal:  Br J Ind Med       Date:  1992-06

8.  Four-year follow-up of effects of toluene diisocyanate exposure on the respiratory system in polyurethane foam manufacturing workers. II. Four-year changes in the effects on the respiratory system.

Authors:  K Omae; T Higashi; T Nakadate; S Tsugane; M Nakaza; H Sakurai
Journal:  Int Arch Occup Environ Health       Date:  1992       Impact factor: 3.015

9.  Four-year follow-up of effects of toluene diisocyanate exposure on the respiratory system in polyurethane foam manufacturing workers. I. Study design and results of the first cross-sectional observation.

Authors:  K Omae; T Nakadate; T Higashi; M Nakaza; Y Aizawa; H Sakurai
Journal:  Int Arch Occup Environ Health       Date:  1992       Impact factor: 3.015

10.  Risk Assessment for Toluene Diisocyanate and Respiratory Disease Human Studies.

Authors:  Robert M Park
Journal:  Saf Health Work       Date:  2020-12-13
  10 in total

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